Zinc Finger and BTB Domain Containing 4 (ZBTB4) (C-Term) antibody

Details for Product No. ABIN783355
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Synonyms KAISO-L1, ZNF903, 2310026P19Rik, 9230111I22Rik, RP23-422L16.16, mKIAA1538
(14), (10), (8), (2)
Human, Mouse (Murine)
(46), (17), (13), (1)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(37), (21), (11), (10), (3), (3), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN783355
401.50 $
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Immunogen 18 amino acid peptide near the carboxy terminus of human ZBTB4
Specificity This antibody detects ZBTB4 (C-term). At least four isoforms of ZBTB4 are known to exist, this antibody will only recognize the longest isoform. This antibody is predicted to not cross-react with other ZBTB protein family members.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name ZBTB4
Background The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.Synonyms: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4
Gene ID 57659
NCBI Accession NP_001122305
UniProt Q9P1Z0
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Background publications Yamada, Pérez-Torrado, Filion et al.: "The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4." in: Oncogene, Vol. 28, Issue 27, pp. 2535-44, 2009 (PubMed).

Weber, Marquardt, Elzi et al.: "Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation." in: The EMBO journal, Vol. 27, Issue 11, pp. 1563-74, 2008 (PubMed).

Filion, Zhenilo, Salozhin et al.: "A family of human zinc finger proteins that bind methylated DNA and repress transcription." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 169-81, 2005 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

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