Zinc Finger and BTB Domain Containing 4 (ZBTB4) (C-Term) antibody

Details for Product No. ABIN783355
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Antigen
Synonyms KAISO-L1, ZNF903, 2310026P19Rik, 9230111I22Rik, RP23-422L16.16, mKIAA1538
Epitope
C-Term
(9), (7), (3), (1)
Reactivity
Human, Mouse (Murine)
(39), (19), (13), (13), (12), (12)
Host
Rabbit
(39)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(30), (19), (12), (10), (3), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN783355
401.50 $
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Immunogen 18 amino acid peptide near the carboxy terminus of human ZBTB4
Specificity This antibody detects ZBTB4 (C-term). At least four isoforms of ZBTB4 are known to exist, this antibody will only recognize the longest isoform. This antibody is predicted to not cross-react with other ZBTB protein family members. Species Reactivity: Tested: Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name ZBTB4
Background The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.
Alternate names: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4
Gene ID 57659
NCBI Accession NP_001122305
UniProt Q9P1Z0
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Filion, Zhenilo, Salozhin et al.: "A family of human zinc finger proteins that bind methylated DNA and repress transcription." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 169-81, 2005 (PubMed).

Weber, Marquardt, Elzi et al.: "Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation." in: The EMBO journal, Vol. 27, Issue 11, pp. 1563-74, 2008 (PubMed).

Yamada, Pérez-Torrado, Filion et al.: "The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4." in: Oncogene, Vol. 28, Issue 27, pp. 2535-44, 2009 (PubMed).

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