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Metabotropic Glutamate Receptor 1 antibody (Glutamate Receptor, Metabotropic 1) APC

Details for Product anti-GRM1 Antibody No. ABIN807922, Supplier: Login to see New
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Synonyms fj39d05, wu:fj39d05, si:ch211-51a19.1, Glura, mGlutR, GB18621, GPRC1A, MGLU1, MGLUR1, SCAR13, 4930455H15Rik, ENSMUSG00000075319, Gm10828, Gprc1a, mGluR1, nmf373, rcw, wobl
Human, Non-Human Primate
(130), (46), (39), (6), (5), (5), (1)
(123), (16), (2), (1)
Clonality (Clone)
Monoclonal ()
This Metabotropic Glutamate Receptor 1 antibody is conjugated to APC
(5), (5), (5), (4), (4), (4), (1), (1)
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
(85), (55), (53), (39), (12), (9), (8), (4), (4), (2), (2), (2), (1), (1), (1), (1)
Pubmed 7 references available
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Quantity 100 tests
Shipping to United States ( )
Availability Will be delivered in 4 to 5 Business Days
Immunogen Human neutrophils
Clone 3G8
Isotype IgG1
Specificity The mouse monoclonal antibody 3G8 recognizes CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA, 50-65 kDa, expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB, 48 kDa, mainly expressed on neutrophils).HLDA V, WS Code NK80
Characteristics The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Alternative Name GRM1 (GRM1 Antibody Abstract)
Background CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms -, FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
Gene ID 2214
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 10 µL reagent / 100 µL of whole blood or 10^6 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.

Working concentrations should be determined by the investigator.

CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)

Restrictions For Research Use only
Reconstitution No reconstitution is necessary.
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store in the dark at 2-8 °C. Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
Product cited in: Burt, Plitas, Zhao et al.: "The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 3, pp. 1789-96, 2009 (PubMed).

Congy-Jolivet, Bolzec, Ternant et al.: "Fc gamma RIIIa expression is not increased on natural killer cells expressing the Fc gamma RIIIa-158V allotype." in: Cancer research, Vol. 68, Issue 4, pp. 976-80, 2008 (PubMed).

Choi, Wang, Peterson et al.: "Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques." in: Immunology, Vol. 124, Issue 2, pp. 215-22, 2008 (PubMed).

Komano, Nanki, Hayashida et al.: "Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts." in: Arthritis research & therapy, Vol. 8, Issue 5, pp. R152, 2007 (PubMed).

Wijngaarden, van Roon, van de Winkel et al.: "Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment." in: Rheumatology (Oxford, England), Vol. 44, Issue 6, pp. 729-34, 2005 (PubMed).

Metes, Ernst, Chambers et al.: "Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene." in: Blood, Vol. 91, Issue 7, pp. 2369-80, 1998 (PubMed).

Background publications Zhu, Hamann, Muñoz et al.: "Intracellular expression of Fc gamma RIII (CD16) and its mobilization by chemoattractants in human eosinophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 5, pp. 2574-9, 1998 (PubMed).

Catalog No. ABIN807922
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