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Details for Product No. ABIN94206

CD6 (CD6) antibody

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Antigen
Synonyms TP120, OX52
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN94206
Quantity 0.1 mg
Price
290.40 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 4 to 5 Business Days
Immunogen Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cellsfollowed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gelcorresponding to the 100 kDa zone).
Clone MEM-98
Isotype IgG1
Specificity The MEM-98 antibody reacts with CD6, a 100-130 kDa single chain transmembraneglycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acutelymphocytic leukemia cells.
Purification Purified from ascites by protein-A affinity chromatography.
Purity > 95% (by SDS-PAGE)
Alternative Name CD6
Background CD6, also known as T12, is a member of the scavenger receptor superfamily found on Tand B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interactswith its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as acoreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAMmediated cell adhesion is also important for T cell proliferation. CD6 may exert some itsfunctions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6has antiapoptotic role in chronic lymphocytic leukemia B cells.
Gene ID 11q13
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Western Blotting. Application note: Non-reducing conditions. Immunohistochemistry (paraffin sections) - Recommended dilution: 10 µg/ml. Positive tissue: spleen
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Storage 4 °C
Hassan, Simmonds, Clarkson et al.: "CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76." in: Molecular and cellular biology, Vol. 26, Issue 17, pp. 6727-38, 2006 (PubMed).

Castro, Oliveira, Nunes et al.: "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4351-61, 2007 (PubMed).

Alternatives for antigen "CD6 (CD6)", type "Antibodies"
Hosts (120), (29), (1)
Reactivities (117), (35), (18), (8), (5)
Applications (124), (54), (43), (24), (17), (15), (15), (11), (10), (10), (5), (1), (1)
Conjugates (21), (14), (12), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (2), (2), (1), (1)
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