Actin-Binding rho Activating Protein (ABRA) (C-Term), (AA 282-312) antibody

Details for Product No. ABIN950219
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Synonyms STARS, C130068O12Rik, Ms1, Stars
C-Term, AA 282-312
(17), (14), (2), (1)
(21), (3)
(21), (1)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(22), (14), (10), (3), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN950219
357.50 $
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Immunogen KLH conjugated synthetic peptide between 282-312 amino acids from the C-terminal region of human ABRA
Isotype Ig
Specificity This antibody reacts to ABRA / STARS.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name ABRA / STARS
Background ABRA acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity).Synonyms: Actin-binding Rho-activating protein, Striated muscle activator of Rho-dependent signaling
Gene ID 137735
NCBI Accession NP_631905
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lamon, Wallace, Léger et al.: "Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy." in: The Journal of physiology, Vol. 587, Issue Pt 8, pp. 1795-803, 2009 (PubMed).

Kuwahara, Teg Pipes, McAnally et al.: "Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity." in: The Journal of clinical investigation, Vol. 117, Issue 5, pp. 1324-34, 2007 (PubMed).

Kuwahara, Barrientos, Pipes et al.: "Muscle-specific signaling mechanism that links actin dynamics to serum response factor." in: Molecular and cellular biology, Vol. 25, Issue 8, pp. 3173-81, 2005 (PubMed).

Arai, Spencer, Olson: "STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription." in: The Journal of biological chemistry, Vol. 277, Issue 27, pp. 24453-9, 2002 (PubMed).

Simpson, Wellenreuther, Poustka et al.: "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing." in: EMBO reports, Vol. 1, Issue 3, pp. 287-92, 2001 (PubMed).

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