Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 170-198), (Middle Region) antibody

Details for Product No. ABIN950550
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Antigen
Synonyms atf-4, atf4, creb-2, creb2, taxreb67, txreb, wu:fj01c08, wu:fk30b04, zgc:85951, ATF4, ATF4C, sb:eu681, wu:fb08f07, zgc:171702, CREB-2, CREB2, TAXREB67, TXREB, Atf-4, C/ATF
Epitope
AA 170-198, Middle Region
(39), (36), (21), (18), (9), (7), (6), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(183), (56), (52), (17), (14), (14), (1), (1), (1), (1)
Host
Rabbit
(141), (44), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (6), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(139), (77), (69), (40), (25), (20), (6), (6), (5), (5), (4), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN950550
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Immunogen KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human ATF4
Isotype Ig
Specificity This antibody reacts to ATF4.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name ATF4
Background This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.Synonyms: ATF-4, Activating transcription factor 4, CREB-2, CREB2, Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, TXREB, cAMP-responsive element-binding protein 2
Gene ID 468
NCBI Accession NP_001666
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Dey, Baird, Zhou et al.: "Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33165-74, 2010 (PubMed).

Frank, Ge, Xie et al.: "Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33324-37, 2010 (PubMed).

Liew, Bochenski, Kawamori et al.: "The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2876-88, 2010 (PubMed).

Wek, Staschke: "How do tumours adapt to nutrient stress?" in: The EMBO journal, Vol. 29, Issue 12, pp. 1946-7, 2010 (PubMed).

Rzymski, Milani, Pike et al.: "Regulation of autophagy by ATF4 in response to severe hypoxia." in: Oncogene, Vol. 29, Issue 31, pp. 4424-35, 2010 (PubMed).

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