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Cation Channel, Sperm Associated 1 (CATSPER1) (N-Term), (AA 35-65) antibody

Details for Product No. ABIN951069
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Antigen
Synonyms CATSPER, SPGF7, Catsper, KSper
Epitope
N-Term, AA 35-65
(8), (7), (2), (1), (1)
Reactivity
Human
(27), (18), (17), (17), (17)
Host
Rabbit
(28)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(14), (14), (6), (3), (2), (2)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN951069
357.50 $
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Immunogen KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human CATSPER1
Specificity This antibody reacts to CATSPER1.
Purification Affinity chromatography on Protein A
Alternative Name CATSPER1
Background Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.
Alternate names: Cation channel sperm-associated protein 1
Gene ID 117144
NCBI Accession NP_444282
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Clapham, Garbers: "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 451-4, 2005 (PubMed).

Li, Liao, Ding et al.: "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa." in: Asian journal of andrology, Vol. 8, Issue 3, pp. 301-6, 2006 (PubMed).

Zhang, Chen, Saraf et al.: "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity." in: The Journal of biological chemistry, Vol. 281, Issue 31, pp. 22332-41, 2006 (PubMed).

Li, Ding, Guan et al.: "Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region." in: Fertility and sterility, Vol. 92, Issue 3, pp. 1141-6, 2009 (PubMed).

Avenarius, Hildebrand, Zhang et al.: "Human male infertility caused by mutations in the CATSPER1 channel protein." in: American journal of human genetics, Vol. 84, Issue 4, pp. 505-10, 2009 (PubMed).

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