Cation Channel, Sperm Associated 1 (CATSPER1) (N-Term), (AA 35-65) antibody

Details for Product No. ABIN951069
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Synonyms CATSPER, SPGF7, Catsper, KSper
N-Term, AA 35-65
(9), (7), (2), (1), (1)
(23), (13), (12), (12), (12)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(15), (10), (10), (6), (3), (2)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN951069
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Immunogen KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human CATSPER1
Isotype Ig
Specificity This antibody reacts to CATSPER1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name CATSPER1
Background Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.Synonyms: Cation channel sperm-associated protein 1
Molecular Weight 90091 Da
Gene ID 117144
NCBI Accession NP_444282
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Avenarius, Hildebrand, Zhang et al.: "Human male infertility caused by mutations in the CATSPER1 channel protein." in: American journal of human genetics, Vol. 84, Issue 4, pp. 505-10, 2009 (PubMed).

Li, Ding, Guan et al.: "Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region." in: Fertility and sterility, Vol. 92, Issue 3, pp. 1141-6, 2009 (PubMed).

Zhang, Chen, Saraf et al.: "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity." in: The Journal of biological chemistry, Vol. 281, Issue 31, pp. 22332-41, 2006 (PubMed).

Li, Liao, Ding et al.: "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa." in: Asian journal of andrology, Vol. 8, Issue 3, pp. 301-6, 2006 (PubMed).

Clapham, Garbers: "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 451-4, 2005 (PubMed).

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