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Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody

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Synonyms CD85H, ILT1, LIR-7, LIR7
AA 62-89, Middle Region
(18), (15), (9), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(42), (9), (1)
(4), (3), (3), (2), (2), (2)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(43), (35), (16), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of Human CD85h / LILRA2
Isotype Ig
Specificity This antibody recognizes Human CD85h / LILRA2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name CD85h / LILRA2 (LILRA2 Antibody Abstract)
Background Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3, MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.Synonyms: CD85 antigen-like family member H, ILT-1, ILT1, Immunoglobulin-like transcript 1, LILRA-2, LIR-7, LIR7, Leukocyte immunoglobulin-like receptor 7, Leukocyte immunoglobulin-like receptor subfamily A member 2
Molecular Weight 52992 Da
Gene ID 11027
NCBI Accession NP_001124389
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -80 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody (ABIN951417) Flow cytometric analysis of A549 cells using CD85h / LILRA2 Antibody (Center) Cat.-No...
Western Blotting (WB) image for anti-Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody (ABIN951417) Western blot analysis of CD85h / LILRA2 Antibody (Center) in NCI-H292,NCI-H460 and A5...
Background publications Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Jones, Roghanian, Brown et al.: "Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes." in: European journal of immunology, Vol. 39, Issue 11, pp. 3195-206, 2010 (PubMed).

Chen, Gao, Chu et al.: "Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes." in: Journal of molecular biology, Vol. 386, Issue 3, pp. 841-53, 2009 (PubMed).

Mamegano, Kuroki, Miyashita et al.: "Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis." in: Genes and immunity, Vol. 9, Issue 3, pp. 214-23, 2008 (PubMed).

Catalog No. ABIN951417
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