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Details for Product No. ABIN951417

Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody

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Antigen
Synonyms CD85H, ILT1, LIR-7, LIR7
Epitope
»Alternatives AA 62-89, Middle Region
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Flow Cytometry (FACS), ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN951417
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of Human CD85h / LILRA2
Specificity This antibody recognizes Human CD85h / LILRA2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name CD85h / LILRA2
Background Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3, MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.
Alternate names: CD85 antigen-like family member H, ILT-1, ILT1, Immunoglobulin-like transcript 1, LILRA-2, LIR-7, LIR7, Leukocyte immunoglobulin-like receptor 7, Leukocyte immunoglobulin-like receptor subfamily A member 2
Molecular Weight 52992 Da
Gene ID 11027
NCBI Accession NP_001124389
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer.
Expiry Date 12 months
Background publications Mamegano, Kuroki, Miyashita et al.: "Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis." in: Genes and immunity, Vol. 9, Issue 3, pp. 214-23, 2008 (PubMed).

Chen, Gao, Chu et al.: "Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes." in: Journal of molecular biology, Vol. 386, Issue 3, pp. 841-53, 2009 (PubMed).

Jones, Roghanian, Brown et al.: "Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes." in: European journal of immunology, Vol. 39, Issue 11, pp. 3195-206, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Alternatives for antigen "Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2)", type "Antibodies"
Hosts (17), (4)
Reactivities (21)
Applications (19), (12), (3), (2), (1)
Epitopes (5), (3), (2), (1), (1), (1), (1)
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