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Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody

Details for Product No. ABIN951417
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Antigen
Synonyms CD85H, ILT1, LIR-7, LIR7
Epitope
AA 62-89, Middle Region
(11), (7), (3), (1), (1), (1), (1), (1)
Reactivity
Human
(30)
Host
Rabbit
(26), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
(28), (22), (7), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN951417
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of Human CD85h / LILRA2
Specificity This antibody recognizes Human CD85h / LILRA2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name CD85h / LILRA2
Background Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3, MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.
Alternate names: CD85 antigen-like family member H, ILT-1, ILT1, Immunoglobulin-like transcript 1, LILRA-2, LIR-7, LIR7, Leukocyte immunoglobulin-like receptor 7, Leukocyte immunoglobulin-like receptor subfamily A member 2
Molecular Weight 52992 Da
Gene ID 11027
NCBI Accession NP_001124389
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer.
Expiry Date 12 months
Background publications Mamegano, Kuroki, Miyashita et al.: "Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis." in: Genes and immunity, Vol. 9, Issue 3, pp. 214-23, 2008 (PubMed).

Chen, Gao, Chu et al.: "Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes." in: Journal of molecular biology, Vol. 386, Issue 3, pp. 841-53, 2009 (PubMed).

Jones, Roghanian, Brown et al.: "Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes." in: European journal of immunology, Vol. 39, Issue 11, pp. 3195-206, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Hosts (26), (4)
Reactivities (30)
Applications (28), (22), (7), (2), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1)
Epitopes (11), (7), (3), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN951417
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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