Claudin 4 (CLDN4) (C-Term), (AA 177-206) antibody

Details for Product No. ABIN951550
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Antigen
Synonyms CLDN4, cper, cpe-r, cpetr, cpetr1, hcpe-r, wbscr8, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, Cep-r, Cpetr, Cpetr1
Epitope
C-Term, AA 177-206
(62), (14), (12), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(117), (51), (38), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(106), (13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(70), (56), (40), (30), (10), (7), (4), (3), (3), (2), (2), (2), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
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Immunogen KLH conjugated synthetic peptide between 177~206 amino acids from the C-terminal region of human CLDN4
Isotype Ig
Specificity This antibody reacts to CLDN4.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Alternative Name Claudin-4 / CLDN4 (CLDN4 Antibody Abstract)
Background CLDN4 is an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life.Synonyms: CPE-R, CPE-Receptor, CPER, CPETR1, Clostridium perfringens enterotoxin receptor, WBSCR8, Williams-Beuren syndrome chromosomal region 8 protein
Molecular Weight 22077 Da
Gene ID 1364
NCBI Accession NP_001296
Research Area Cytoskeleton
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Seckin, Arici, Harputluoglu et al.: "Expression of claudin-4 and beta-catenin in gastric premalignant lesions." in: Acta gastro-enterologica Belgica, Vol. 72, Issue 4, pp. 407-12, 2010 (PubMed).

Papageorgis, Lambert, Ozturk et al.: "Smad signaling is required to maintain epigenetic silencing during breast cancer progression." in: Cancer research, Vol. 70, Issue 3, pp. 968-78, 2010 (PubMed).

Kimura, Abe, Kamitani et al.: "Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction." in: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 401-8, 2009 (PubMed).

Robertson, Smedley, McClane: "Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin." in: Infection and immunity, Vol. 78, Issue 1, pp. 505-17, 2009 (PubMed).

Validation Images
Catalog No. ABIN951550
357.50 $
Plus shipping costs $45.00
Quantity
Price
0.4 mL
357.50 $

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