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Complex IV Subunit VIIa (AA 9-38), (Middle Region) antibody

Details for Product No. ABIN951655, Supplier: Log in to see
Antigen
Epitope
AA 9-38, Middle Region
Reactivity
Human, Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Immunogen KLH conjugated synthetic peptide between 9-38 amino acids from the Central region of human COX7A1
Isotype Ig
Specificity This antibody reacts to COX7A1.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Affinity chromatography on Protein A
Background Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.Synonyms: COX7A1, COX7AH, Cytochrome c oxidase polypeptide 7A1
Molecular Weight 9118 Da
Gene ID 1346
NCBI Accession NP_001855
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Complex IV Subunit VIIa (AA 9-38), (Middle Region) antibody (ABIN951655) COX7A1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35...
Background publications Lazarou, Smith, Thorburn et al.: "Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria." in: The FEBS journal, Vol. 276, Issue 22, pp. 6701-13, 2010 (PubMed).

Rönn, Poulsen, Hansson et al.: "Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle." in: Diabetologia, Vol. 51, Issue 7, pp. 1159-68, 2008 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19. ..." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).