Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (AA 143-172), (Middle Region) antibody

Details for Product No. ABIN951788
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Synonyms zgc:112062, CYSLTR1, CYSLT1, CYSLT1R, CYSLTR, HMTMF81, BB147369, CysLT1R, Cyslt1, cysLT1R
AA 143-172, Middle Region
(14), (14), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(58), (2), (1), (1)
(58), (1)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(50), (35), (24), (18), (13), (3), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN951788
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Immunogen KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of Human CYSLTR1. Genename: CYSLTR1
Isotype Ig
Specificity This antibody recognizes Human CYSLTR1 (Center).
Purification Affinity Chromatography on Protein A
Alternative Name CYSLTR1
Background The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.Synonyms: CysLTR1, Cysteinyl leukotriene D4 receptor, Cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, HG55, HMTMF81, LTD4 receptor
Molecular Weight 38541 Da
Gene ID 10800
NCBI Accession NP_006630
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Schuurhof, Bont, Siezen et al.: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010 (PubMed).

Boulay, Duchesneau, Jacques et al.: "CysLT1-R expression following allergen provocation in asthma and allergic rhinitis." in: Prostaglandins, leukotrienes, and essential fatty acids, Vol. 83, Issue 1, pp. 15-22, 2010 (PubMed).

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