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ERI1 Exoribonuclease Family Member 2 (EXOD1) (AA 443-472), (Middle Region) antibody

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Synonyms exod1, EXOD1, Exod1, 4933424N09Rik, mKIAA1504, eri2
AA 443-472, Middle Region
(15), (15), (10), (4), (2), (2), (2), (1)
(31), (5), (2), (1), (1), (1), (1)
(28), (3)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(29), (16), (3), (1)
Pubmed 3 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 443-472 amino acids from the Central region of Human EXOD1 Genename: ERI2
Isotype Ig
Specificity This antibody recognizes Human EXOD1 (Center).
Purification Affinity Chromatography on Protein A
Alternative Name EXOD1
Background EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides. EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit. There are four isoforms of EXOD1 that are produced as a result of alternative splicing events. The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3 % of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.Synonyms: Exonuclease domain-containing protein 1, KIAA1504, MGC16943
Molecular Weight 77401 Da
Gene ID 112479
NCBI Accession NP_001136197
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ERI1 Exoribonuclease Family Member 2 (EXOD1) (AA 443-472), (Middle Region) antibody (ABIN952142) Western blot analysis of EXOD1  Antibody  in HL-60 cell line lysates (35ug/lane). Thi...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Kupsco, Wu, Marzluff et al.: "Genetic and biochemical characterization of Drosophila Snipper: A promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5' exonucleases." in: RNA (New York, N.Y.), Vol. 12, Issue 12, pp. 2103-17, 2006 (PubMed).

Catalog No. ABIN952142
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