Heat Shock 70kDa Protein 9 (Mortalin) (HSPA9) (AA 280-309), (Middle Region) antibody

Details for Product No. ABIN952636
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Antigen
Synonyms
csa, grp-75, grp75, hspa9, hspa9b, mortalin, mot, mot2, pbp74, mot-2, mthsp75, HSPA9B, CSA, GRP-75, GRP75, MOT, MOT2, MTHSP75, PBP74, 74kDa, Csa, Grp75, Hsc74, Hsp74, Hsp74a, Hspa9a, Mortalin, Mot-2,  ... show more
csa, grp-75, grp75, hspa9, hspa9b, mortalin, mot, mot2, pbp74, mot-2, mthsp75, HSPA9B, CSA, GRP-75, GRP75, MOT, MOT2, MTHSP75, PBP74, 74kDa, Csa, Grp75, Hsc74, Hsp74, Hsp74a, Hspa9a, Mortalin, Mot-2, Mot2, Mthsp70, Pbp74 show less
Epitope
AA 280-309, Middle Region
(9), (7), (7), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(102), (45), (42), (16), (12), (12), (3), (2), (2), (2)
Host
Rabbit
(65), (40)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(84), (47), (27), (24), (23), (19), (11), (10), (6), (6), (4), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN952636
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Immunogen KLH conjugated synthetic peptide between 280-309 amino acids from the Central region of human Grp75 / HSPA9
Isotype Ig
Specificity This antibody recognizes Human Grp75 / HSPA9B (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Grp75 / HSPA9
Background This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.Synonyms: 75 kDa glucose-regulated protein, HSPA9B, Heat shock 70 kDa protein 9, MOT, Mortalin, PBP74, Peptide-binding protein 74, Stress-70 protein
Molecular Weight 73680 Da
Gene ID 3313
NCBI Accession NP_004125
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Goswami, Chittoor, DSilva: "Understanding the functional interplay between mammalian mitochondrial Hsp70 chaperone machine components." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 19472-82, 2010 (PubMed).

Li, Xu, Ling et al.: "mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells." in: Environmental health perspectives, Vol. 118, Issue 7, pp. 936-42, 2010 (PubMed).

Iosefson, Azem: "Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions." in: FEBS letters, Vol. 584, Issue 6, pp. 1080-4, 2010 (PubMed).

Luo, Dizin, Yoon et al.: "Kinetic and structural characterization of human mortalin." in: Protein expression and purification, Vol. 72, Issue 1, pp. 75-81, 2010 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

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