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H2A Histone Family, Member Y2 (H2AFY2) (AA 14-43), (N-Term) antibody

Details for Product No. ABIN952667, Supplier: Login to see
Antigen
  • RGD1561371
  • MGC69037
  • MGC130768
  • macroh2a2
  • im:6898017
  • wu:fa14g05
  • zgc:114051
  • macroH2A2
Epitope
N-Term, AA 14-43
16
16
15
4
3
3
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
58
8
5
Host
Rabbit
42
16
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
50
18
14
5
5
2
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of Human H2AFY2 / MACROH2A2
Isotype Ig
Specificity This antibody recognizes Human and Mouse H2AFY2 / MACROH2A2 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name H2AFY2 / MACROH2A2 (H2AFY2 Antibody Abstract)
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.Synonyms: Core histone macro-H2A.2, Histone macroH2A2, mH2A2
Molecular Weight 40058 Da
Gene ID 55506
NCBI Accession NP_061119
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-H2A Histone Family, Member Y2 (H2AFY2) (AA 14-43), (N-Term) antibody (ABIN952667) Flow cytometric analysis of Hela cells using H2AFY2 / MACROH2A2 Antibody (N-term) Cat...
Western Blotting (WB) image for anti-H2A Histone Family, Member Y2 (H2AFY2) (AA 14-43), (N-Term) antibody (ABIN952667) Western blot analysis of H2AFY2 / MACROH2A2 Antibody (N-term) in mouse liver tissue l...
Background publications Xu, Zheng, Isaacs et al.: "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2136-40, 2010 (PubMed).

Sporn, Kustatscher, Hothorn et al.: "Histone macroH2A isoforms predict the risk of lung cancer recurrence." in: Oncogene, Vol. 28, Issue 38, pp. 3423-8, 2009 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Zhang, Poustovoitov, Ye et al.: "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA." in: Developmental cell, Vol. 8, Issue 1, pp. 19-30, 2004 (PubMed).