Histone Deacetylase 11 (HDAC11) (AA 196-226), (Middle Region) antibody

Details for Product No. ABIN952697
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Antigen
Synonyms CG31119, DHDACX, Dmel\\CG31119, HDAC11, HDACX, dHDAC11, dmHDA403, zgc:91942, HD11
Epitope
AA 196-226, Middle Region
(11), (11), (8), (8), (7), (4), (3), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(67), (31), (20), (12), (12), (1), (1), (1)
Host
Rabbit
(63), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(63), (33), (18), (10), (10), (7), (3), (3), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Request Want additional data for this product?

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Catalog No. ABIN952697
357.50 $
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Immunogen KLH conjugated synthetic peptide between 196-226 amino acids from the Central region of human HDAC11
Isotype Ig
Specificity This antibody recognizes Human and Mouse HDAC11 (Center).
Cross-Reactivity (Details) Species reactivity (expected):Monkey.
Purification Protein A column, followed by peptide affinity purification
Alternative Name HDAC11
Background This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Cellular Location: Nucleus. Note=Predominantly nuclear. Tissue Location: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testisSynonyms: HD11, Histone deacetylase 11
Molecular Weight 39183 Da
Gene ID 79885
NCBI Accession NP_079103
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors, Wnt Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Fournel, Bonfils, Hou et al.: "MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 759-68, 2008 (PubMed).

Villagra, Cheng, Wang et al.: "The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance." in: Nature immunology, Vol. 10, Issue 1, pp. 92-100, 2008 (PubMed).

Georgopoulos: "From immunity to tolerance through HDAC." in: Nature immunology, Vol. 10, Issue 1, pp. 13-4, 2008 (PubMed).

Glozak, Seto: "Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11446-53, 2009 (PubMed).

Janssen, Schmalbach, Boeselt et al.: "Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 6, pp. 573-81, 2010 (PubMed).

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