Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 238-268), (Middle Region) antibody

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Synonyms Kv1.3-glyb, kv1.3, Kv1.3B, kcna3b-a, HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, Kca1-3, Kv1.3, Mk-3, cKv1.1
AA 238-268, Middle Region
(22), (19), (17), (17), (17), (15), (8), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(100), (53), (51), (2), (2), (2), (2), (2)
(76), (26)
(5), (5), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(78), (46), (36), (20), (16), (10), (8), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 238-268 amino acids from the Central region of human KCNA3
Isotype Ig
Specificity This antibody recognizes Human KCNA3 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KCNA3 (KCNA3 Antibody Abstract)
Background Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.Synonyms: HGK5, HLK3, HPCN3, HuKIII, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3
Molecular Weight 63842 Da
Gene ID 3738
NCBI Accession NP_002223
Research Area Signaling, Metabolism
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Wang, Lee, Johnson et al.: "Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 14, pp. 5020-7, 2010 (PubMed).

Tu, Deutsch: "A folding zone in the ribosomal exit tunnel for Kv1.3 helix formation." in: Journal of molecular biology, Vol. 396, Issue 5, pp. 1346-60, 2010 (PubMed).

Feng, Zhang, Ma et al.: "[Kv1.3 potassium channel expression changes after CD4(+) and subsets CD28(null)/CD28(+)T cells activation in peripheral blood of patients with acute coronary syndrome]." in: Zhonghua xin xue guan bing za zhi, Vol. 37, Issue 7, pp. 599-604, 2009 (PubMed).

Nicolaou, Neumeier, Takimoto et al.: "Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus." in: Cell calcium, Vol. 47, Issue 1, pp. 19-28, 2010 (PubMed).

Poulopoulou, Markakis, Davaki et al.: "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." in: Neurobiology of disease, Vol. 37, Issue 2, pp. 339-48, 2010 (PubMed).

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Catalog No. ABIN952995
$ 357.50
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0.4 mL
$ 357.50

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