Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 238-268), (Middle Region) antibody

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Antigen
Synonyms Kv1.3-glyb, MK3, HGK5, HLK3, PCN3, HPCN3, KV1.3, HUKIII, Mk-3, Kv1.3, Kca1-3, kv1.3, Kv1.3B, kcna3b-a, cKv1.1
Epitope
AA 238-268, Middle Region
(17), (8), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(64), (40), (38), (24), (24), (12), (12), (2)
Host
Rabbit
(58), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(38), (25), (23), (20), (12), (11), (3), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN952995
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 238-268 amino acids from the Central region of human KCNA3
Specificity This antibody recognizes Human KCNA3 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KCNA3
Background Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
Alternate names: HGK5, HLK3, HPCN3, HuKIII, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3
Molecular Weight 63842 Da
Gene ID 3738
NCBI Accession NP_002223
Research Area Signaling, Metabolism
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Poulopoulou, Markakis, Davaki et al.: "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." in: Neurobiology of disease, Vol. 37, Issue 2, pp. 339-48, 2010 (PubMed).

Nicolaou, Neumeier, Takimoto et al.: "Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus." in: Cell calcium, Vol. 47, Issue 1, pp. 19-28, 2010 (PubMed).

Feng, Zhang, Ma et al.: "[Kv1.3 potassium channel expression changes after CD4(+) and subsets CD28(null)/CD28(+)T cells activation in peripheral blood of patients with acute coronary syndrome]." in: Zhonghua xin xue guan bing za zhi, Vol. 37, Issue 7, pp. 599-604, 2009 (PubMed).

Tu, Deutsch: "A folding zone in the ribosomal exit tunnel for Kv1.3 helix formation." in: Journal of molecular biology, Vol. 396, Issue 5, pp. 1346-60, 2010 (PubMed).

Wang, Lee, Johnson et al.: "Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 14, pp. 5020-7, 2010 (PubMed).

Hosts (58), (9)
Reactivities (64), (40), (38), (24), (24), (12), (12), (2)
Applications (38), (25), (23), (20), (12), (11), (3), (2), (2), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (8), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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