Potassium Channel Regulator (KCNRG) (C-Term), (AA 182-210) antibody

Details for Product No. ABIN953017
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C-Term, AA 182-210
Human, Mouse (Murine)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN953017
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Immunogen KLH conjugated synthetic peptide between 182-210 amino acids from the C-terminal region of human KCNRG
Isotype Ig
Specificity This antibody recognizes Human and Mouse KCNRG (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KCNRG
Background This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene.Synonyms: CLLD4, KCNRG, Potassium channel regulator, Potassium channel regulatory protein, Protein CLLD4
Molecular Weight 31048 Da
Gene ID 10206
NCBI Accession NP_001007279
Research Area Cancer
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lerner, Corcoran, Cepeda et al.: "The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD." in: Molecular biology of the cell, Vol. 18, Issue 5, pp. 1670-82, 2007 (PubMed).

Skoblov, Shakhbazov, Oshchepkov et al.: "Human RFP2 gene promoter: unique structure and unusual strength." in: Biochemical and biophysical research communications, Vol. 342, Issue 3, pp. 859-66, 2006 (PubMed).

Corcoran, Hammarsund, Zhu et al.: "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse." in: Genes, chromosomes & cancer, Vol. 40, Issue 4, pp. 285-97, 2004 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

van Everdink, Baranova, Lummen et al.: "RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia." in: Cancer genetics and cytogenetics, Vol. 146, Issue 1, pp. 48-57, 2003 (PubMed).

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