Kallikrein-Related Peptidase 12 (KLK12) (AA 84-113), (Middle Region) antibody

Details for Product No. ABIN953100
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Synonyms KLK12, 2310008B01Rik, AI324852, KLK-L5, KLKL5
AA 84-113, Middle Region
(13), (11), (7), (1)
(33), (1), (1)
(2), (2), (2), (2), (2), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(32), (12), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN953100
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Immunogen KLH conjugated synthetic peptide between 84-113 amino acids from the Central region of Human KLK12 / Kallikrein-12
Isotype Ig
Specificity This antibody recognizes Human KLK12 / Kallikrein-12 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KLK12 / Kallikrein-12
Background Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq].Synonyms: KLK-L5, KLKL5, Kallikrein-like protein 5
Molecular Weight 26734 Da
Gene ID 43849
NCBI Accession NP_062544
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Klein, Halldén, Cronin et al.: "Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 611-9, 2010 (PubMed).

Memari, Jiang, Diamandis et al.: "Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)." in: Biological chemistry, Vol. 388, Issue 4, pp. 427-35, 2007 (PubMed).

Lundwall, Band, Blaber et al.: "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins." in: Biological chemistry, Vol. 387, Issue 6, pp. 637-41, 2006 (PubMed).

Shinmura, Tao, Yamada et al.: "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity." in: Human mutation, Vol. 24, Issue 3, pp. 273-4, 2004 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19. ..." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

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