MAD2L1 Binding Protein (MAD2L1BP) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN953277
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Antigen
Synonyms MAD2L1BP, CMT2, RP1-261G23.6, 0610009D16Rik, 2510031P20Rik, AU018945, AW550977, C76045, CMT2A, CMT2B, Mad2lbp, mKIAA0110
Epitope
N-Term, AA 1-30
(12), (7), (3), (3), (1), (1)
Reactivity
Human
(30), (6), (3)
Host
Rabbit
(25), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(30), (14), (4), (4), (3)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN953277
357.50 $
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Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of Human MAD2L1-binding protein Genename: MAD2L1BP
Specificity This antibody recognizes Human MAD2L1-binding protein (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name MAD2L1-binding protein
Background The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alternate names: CMT2, MAD2L1BP
Molecular Weight 31052 Da
Gene ID 9587
NCBI Accession NP_001003690
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Yun, Kim, Park et al.: "Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma." in: Experimental & molecular medicine, Vol. 39, Issue 4, pp. 508-13, 2007 (PubMed).

Yang, Li, Tomchick et al.: "p31comet blocks Mad2 activation through structural mimicry." in: Cell, Vol. 131, Issue 4, pp. 744-55, 2007 (PubMed).

Venkatesan, Rual, Vazquez et al.: "An empirical framework for binary interactome mapping...." in: Nature methods, Vol. 6, Issue 1, pp. 83-90, 2008 (PubMed).

Yun, Han, Yoon et al.: "p31comet Induces cellular senescence through p21 accumulation and Mad2 disruption." in: Molecular cancer research : MCR, Vol. 7, Issue 3, pp. 371-82, 2009 (PubMed).

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