Mediator Complex Subunit 16 (MED16) (AA 252-281), (Middle Region) antibody

Details for Product No. ABIN953369
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Antigen
Synonyms DRIP92, THRAP5, TRAP95, 95kDa, Thrap5, Trap95, A630083L04, MED16
Epitope
AA 252-281, Middle Region
(5), (4), (2), (2), (1), (1)
Reactivity
Human
(19), (3), (3), (3), (1)
Host
Rabbit
(12), (7)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(18), (5), (4), (2), (1)
Pubmed 5 references available
Catalog no. ABIN953369
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 252-281 amino acids from the Central region of human MED16
Specificity This antibody recognizes Human MED16 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name MED16
Background Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Alternate names: DRIP92, Mediator complex subunit 16, Mediator of RNA polymerase II transcription subunit 16, THRAP5, Thyroid hormone receptor-associated protein complex 95 kDa component, Vitamin D3 receptor-interacting protein complex component DRIP92
Molecular Weight 72kd
Gene ID 10025
NCBI Accession NP_005472
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Suzuki, Tsunoda, Sese et al.: "Identification and characterization of the potential promoter regions of 1031 kinds of human genes." in: Genome research, Vol. 11, Issue 5, pp. 677-84, 2001 (PubMed).

Kang, Guermah, Yuan et al.: "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 5, pp. 2642-7, 2002 (PubMed).

Wang, Sharma, Ren et al.: "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 42852-8, 2002 (PubMed).

Tomomori-Sato, Sato, Parmely et al.: "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 5846-51, 2004 (PubMed).

Sato, Tomomori-Sato, Parmely et al.: "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." in: Molecular cell, Vol. 14, Issue 5, pp. 685-91, 2004 (PubMed).

Hosts (12), (7)
Reactivities (19), (3), (3), (3), (1)
Applications (18), (5), (4), (2), (1)
Epitopes (5), (4), (2), (2), (1), (1)
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