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Methyltransferase Like 1 (METTL1) (AA 154-183), (Middle Region) antibody

Details for Product No. ABIN953396, Supplier: Log in to see
Antigen
  • Dmel\\CG4045
  • EG:22E5.4
  • C12orf1
  • TRM8
  • TRMT8
  • YDL201w
  • 2810012D02Rik
Epitope
AA 154-183, Middle Region
15
14
10
2
2
2
1
1
1
1
1
Reactivity
Human
38
8
8
1
Host
Rabbit
36
2
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
34
24
6
2
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 154~183 amino acids from the Central region of human METTL1
Isotype Ig
Specificity This antibody reacts to METTL1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name METTL1 (METTL1 Antibody Abstract)
Background This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation.Synonyms: C12orf1, Methyltransferase-like protein 1, tRNA (guanine-N(7)-)-methyltransferase, tRNA(m7G46)-methyltransferas
Molecular Weight 31471 Da
Gene ID 4234
NCBI Accession NP_005362
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Methyltransferase Like 1 (METTL1) (AA 154-183), (Middle Region) antibody (ABIN953396) Western blot analysis of METTL1 Antibody (Center) in Ramos cell line lysates (35µg/la...
Background publications Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

"Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20." in: Nature genetics, Vol. 41, Issue 7, pp. 824-8, 2009 (PubMed).

Cartlidge, Knebel, Peggie et al.: "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells." in: The EMBO journal, Vol. 24, Issue 9, pp. 1696-705, 2005 (PubMed).

Alexandrov, Martzen, Phizicky: "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA." in: RNA (New York, N.Y.), Vol. 8, Issue 10, pp. 1253-66, 2002 (PubMed).