Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) (C-Term), (AA 425-454) antibody

Details for Product No. ABIN953408
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Synonyms MGAT3, mgat3, zgc:112067, 1110038J12Rik, AI848272, GnT-III, GNT-III, GNT3
C-Term, AA 425-454
(18), (16), (14), (2), (2), (2), (2), (2), (1), (1)
(50), (5), (2)
(46), (4)
(4), (4), (4), (4), (4), (4)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(48), (28), (20), (6), (5), (4), (3), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN953408
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Immunogen KLH conjugated synthetic peptide between 425-454 amino acids from the C-terminal region of human MGAT3
Isotype Ig
Specificity This antibody reacts to MGAT3.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name MGAT3
Background There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: 4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, Beta-1, GGNT3
Molecular Weight 61313 Da
Gene ID 4248
NCBI Accession NP_001091740
Research Area Organelles
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Benson, Grobarova, Richter et al.: "Glycosylation regulates NK cell-mediated effector function through PI3K pathway." in: International immunology, Vol. 22, Issue 3, pp. 167-77, 2010 (PubMed).

Akasaka-Manya, Manya, Sakurai et al.: "Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease." in: Glycobiology, Vol. 20, Issue 1, pp. 99-106, 2009 (PubMed).

Pinho, Reis, Paredes et al.: "The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin." in: Human molecular genetics, Vol. 18, Issue 14, pp. 2599-608, 2009 (PubMed).

Sato, Isaji, Tajiri et al.: "An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11873-81, 2009 (PubMed).

Fiala, Liu, Espinosa-Jeffrey et al.: "Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 31, pp. 12849-54, 2007 (PubMed).

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