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Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody

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Synonyms 2A-DUB, 2ADUB, RP4-592A1.1, C130067A03Rik, C530050H10Rik, RGD1311787, 2adub
N-Term, AA 118-147
(16), (15), (2), (2), (1), (1), (1), (1)
Human, Mouse (Murine)
(60), (18), (16)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(39), (26), (16), (14), (11), (4), (2)
Pubmed 4 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 118-147aa) of human MYSM1
Isotype Ig
Specificity This antibody recognizes MYSM1 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name MYSM1 (MYSM1 Antibody Abstract)
Background Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Synonyms: Histone H2A deubiquitinase MYSM1, KIAA1915, Myb-like SWIRM and MPN domain-containing protein 1
Gene ID 114803
NCBI Accession NP_001078956
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody (ABIN953592) Flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative ...
Western Blotting (WB) image for anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody (ABIN953592) Western blot analysis in MDA-MB231 cell line lysates (35ug/lane) using MYSM1 Antibody...
Western Blotting (WB) image for anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody (ABIN953592) Western blot analysis in mouse kidney tissue lysates (35ug/lane) using MYSM1 Antibody...
Product cited in: Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Background publications Zhu, Zhou, Wang et al.: "A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation." in: Molecular cell, Vol. 27, Issue 4, pp. 609-21, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Yoneyama, Tochio, Umehara et al.: "Structural and functional differences of SWIRM domain subtypes." in: Journal of molecular biology, Vol. 369, Issue 1, pp. 222-38, 2007 (PubMed).

Catalog No. ABIN953592
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