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Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody

Details for Product No. ABIN953592, Supplier: Login to see
Antigen
  • 2A-DUB
  • 2ADUB
  • RP4-592A1.1
  • C130067A03Rik
  • C530050H10Rik
  • RGD1311787
  • 2adub
Epitope
N-Term, AA 118-147
16
15
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
60
18
16
Host
Rabbit
60
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
39
26
16
14
11
4
2
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 118-147aa) of human MYSM1
Isotype Ig
Specificity This antibody recognizes MYSM1 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name MYSM1 (MYSM1 Antibody Abstract)
Background Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Synonyms: Histone H2A deubiquitinase MYSM1, KIAA1915, Myb-like SWIRM and MPN domain-containing protein 1
Gene ID 114803
NCBI Accession NP_001078956
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody (ABIN953592) Flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative ...
Western Blotting (WB) image for anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody (ABIN953592) Western blot analysis in MDA-MB231 cell line lysates (35ug/lane) using MYSM1 Antibody...
Western Blotting (WB) image for anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibody (ABIN953592) Western blot analysis in mouse kidney tissue lysates (35ug/lane) using MYSM1 Antibody...
Product cited in: Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Background publications Zhu, Zhou, Wang et al.: "A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation." in: Molecular cell, Vol. 27, Issue 4, pp. 609-21, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Yoneyama, Tochio, Umehara et al.: "Structural and functional differences of SWIRM domain subtypes." in: Journal of molecular biology, Vol. 369, Issue 1, pp. 222-38, 2007 (PubMed).