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Details for Product No. ABIN953592

Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (N-Term), (AA 118-147) antibody

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Synonyms C130067A03Rik, C530050H10Rik, 2A-DUB, 2ADUB, RP4-592A1.1, 2adub, RGD1311787
»Alternatives N-Term, AA 118-147
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Flow Cytometry (FACS), ELISA, Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN953592
Quantity 0.4 mL
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 118-147aa) of human MYSM1
Specificity This antibody recognizes MYSM1 at N-term.
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name MYSM1
Background Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Alternate names: Histone H2A deubiquitinase MYSM1, KIAA1915, Myb-like SWIRM and MPN domain- containing protein 1
Gene ID 114803
NCBI Accession NP_001078956
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Yoneyama, Tochio, Umehara et al.: "Structural and functional differences of SWIRM domain subtypes." in: Journal of molecular biology, Vol. 369, Issue 1, pp. 222-38, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Zhu, Zhou, Wang et al.: "A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation." in: Molecular cell, Vol. 27, Issue 4, pp. 609-21, 2007 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Alternatives for antigen "Myb-Like, SWIRM and MPN Domains 1 (MYSM1)", type "Antibodies"
Hosts (30)
Reactivities (30), (16), (12)
Applications (16), (10), (10), (8), (3), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (1), (1)