Chromosome 14 Open Reading Frame 49 (C14orf49) (C-Term), (AA 855-884) antibody

Details for Product No. ABIN953651
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Antigen
Synonyms C14orf49, NET53, Nesp3, 4831426I19Rik, nesprin-3
Epitope
C-Term, AA 855-884
(7), (6), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(16), (9)
Host
Rabbit
(17), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(18), (13), (6), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN953651
357.50 $
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Immunogen KLH conjugated synthetic peptide between 855-884 amino acids from the C-terminal region of human SYNE3
Specificity This antibody reacts tp SYNE3.
Purification Affinity chromatography on Protein A
Alternative Name Nesprin-3
Background Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.
Alternate names: C14orf49
Gene ID 161176
NCBI Accession NP_689805
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).

Wilhelmsen, Litjens, Kuikman et al.: "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin." in: The Journal of cell biology, Vol. 171, Issue 5, pp. 799-810, 2005 (PubMed).

Stewart-Hutchinson, Hale, Wirtz et al.: "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." in: Experimental cell research, Vol. 314, Issue 8, pp. 1892-905, 2008 (PubMed).

Nery, Zeng, Niland et al.: "TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton." in: Journal of cell science, Vol. 121, Issue Pt 20, pp. 3476-86, 2008 (PubMed).

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