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Details for Product No. ABIN953651

Chromosome 14 Open Reading Frame 49 (C14orf49) (C-Term), (AA 855-884) antibody

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Antigen
Synonyms C14orf49, NET53, Nesp3, 4831426I19Rik, nesprin-3
Epitope
»Alternatives C-Term, AA 855-884
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN953651
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days

Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen KLH conjugated synthetic peptide between 855-884 amino acids from the C-terminal region of human SYNE3
Specificity This antibody reacts tp SYNE3.
Purification Affinity chromatography on Protein A

Target Details

Application Details Handling References Alternatives back to top
Alternative Name Nesprin-3
Background Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.
Alternate names: C14orf49
Gene ID 161176
NCBI Accession NP_689805

Application Details

Target Details Handling References Alternatives back to top
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months

References

Target Details Application Details Handling Alternatives back to top
Background publications Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).

Wilhelmsen, Litjens, Kuikman et al.: "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin." in: The Journal of cell biology, Vol. 171, Issue 5, pp. 799-810, 2005 (PubMed).

Stewart-Hutchinson, Hale, Wirtz et al.: "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." in: Experimental cell research, Vol. 314, Issue 8, pp. 1892-905, 2008 (PubMed).

Nery, Zeng, Niland et al.: "TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton." in: Journal of cell science, Vol. 121, Issue Pt 20, pp. 3476-86, 2008 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Chromosome 14 Open Reading Frame 49 (C14orf49)", type "Antibodies"
Hosts (6), (1)
Reactivities (6), (6)
Applications (7), (5), (1), (1)
Epitopes (1), (1), (1)
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