Hypocretin (Orexin) Receptor 1 (HCRTR1) (Middle Region), (AA 269-298) antibody

Details for Product No. ABIN953936
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Antigen
Synonyms HCRTR1, OX1R, Ox1r, Hctr1
Epitope
Middle Region, AA 269-298
(15), (7), (7), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(54), (25), (19), (1), (1), (1), (1)
Host
Rabbit
(54), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(37), (31), (15), (5), (2), (2), (2)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN953936
357.50 $
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Immunogen KLH conjugated synthetic peptide between 269-298 amino acids from the Central region of Human Orexin receptor type 1 (Center) Genename: HCRTR1
Specificity This antibody recognizes Human Orexin receptor type 1 (Center)
Purification Protein A column, followed by peptide affinity purification
Alternative Name Orexin receptor type 1
Background The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.
Alternate names: HCRTR1, Hypocretin receptor type 1, Ox1r
Molecular Weight 47536 Da
Gene ID 3061
NCBI Accession NP_001516
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications El Firar, Voisin, Rouyer-Fessard et al.: "Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4069-80, 2009 (PubMed).

Turunen, Ekholm, Somerharju et al.: "Arachidonic acid release mediated by OX1 orexin receptors." in: British journal of pharmacology, Vol. 159, Issue 1, pp. 212-21, 2010 (PubMed).

Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Peltonen, Akerman, Bart: "A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation." in: Biochimica et biophysica acta, Vol. 1803, Issue 10, pp. 1206-12, 2010 (PubMed).

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