P21-Activated Kinase 6 (PAK6) (AA 275-305), (Middle Region) antibody

Details for Product No. ABIN953980
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Antigen
Synonyms pak6, si:ch211-158b22.3, PAK5, 4732456M09
Epitope
AA 275-305, Middle Region
(12), (8), (6), (6), (5), (5), (5), (5), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(94), (31), (30), (19), (14), (12), (12), (2)
Host
Rabbit
(94), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(65), (29), (22), (20), (20), (16), (4), (4), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN953980
357.50 $
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Immunogen KLH conjugated synthetic peptide between 275-305 amino acids from the Central region of human PAK6
Specificity This antibody recognizes Human PAK6 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PAK6
Background This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Alternate names: PAK-5, PAK-6, PAK5, Serine/threonine-protein kinase PAK 6, p21-activated kinase 6
Molecular Weight 74869 Da
Gene ID 56924
NCBI Accession NP_001122100
Research Area Signaling, Kinases/Phosphatases
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Shen, Vermeulen, Rajaraman et al.: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." in: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, 2009 (PubMed).

Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Lee, Mcclelland, Wang et al.: "Distinct DNA methylation profiles between adenocarcinoma and squamous cell carcinoma of human uterine cervix." in: Oncology research, Vol. 18, Issue 9, pp. 401-8, 2010 (PubMed).

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