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PEAR1 antibody (Platelet Endothelial Aggregation Receptor 1) (AA 968-998)

Details for Product anti-PEAR1 Antibody No. ABIN954080, Supplier: Log in to see
Antigen
  • MEGF12
  • JEDI
  • 3110045G13Rik
  • Jedi-1
  • Megf12
  • RGD1305653
Epitope
AA 968-998, C-Term
22
15
6
1
1
Reactivity
Human
31
7
6
Host
Rabbit
25
4
2
1
Clonality
Polyclonal
Conjugate
This PEAR1 antibody is un-conjugated
4
4
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
27
24
18
7
2
2
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 968-998 amino acids from the C-terminal region of human PEAR1
Isotype Ig
Specificity This antibody recognizes Human PEAR1 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PEAR1 (PEAR1 Antibody Abstract)
Background PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).Synonyms: MEGF12, Multiple EGF-like domains protein 12, Multiple epidermal growth factor-like domains protein 12, Platelet endothelial aggregation receptor 1
Molecular Weight 110666 Da
Gene ID 375033
NCBI Accession NP_001073940
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-PEAR1 antibody (Platelet Endothelial Aggregation Receptor 1) (AA 968-998) (ABIN954080) Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney ti...
Western Blotting (WB) image for anti-PEAR1 antibody (Platelet Endothelial Aggregation Receptor 1) (AA 968-998) (ABIN954080) Western blot analysis of PEAR1 Antibody (C-term) in MDA-MB435 cell line lysates (35ug...
Background publications Johnson, Yanek, Chen et al.: "Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists." in: Nature genetics, Vol. 42, Issue 7, pp. 608-13, 2010 (PubMed).

Jones, Bray, Garner et al.: "A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways." in: Blood, Vol. 114, Issue 7, pp. 1405-16, 2009 (PubMed).

Herrera-Galeano, Becker, Wilson et al.: "A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 8, pp. 1484-90, 2008 (PubMed).

Nanda, Bao, Lin et al.: "Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24680-9, 2005 (PubMed).