Platelet Endothelial Aggregation Receptor 1 (PEAR1) (C-Term), (AA 968-998) antibody

Details for Product No. ABIN954080
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Antigen
Epitope
C-Term, AA 968-998
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN954080
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Immunogen KLH conjugated synthetic peptide between 968-998 amino acids from the C-terminal region of human PEAR1
Isotype Ig
Specificity This antibody recognizes Human PEAR1 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PEAR1
Background PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).Synonyms: MEGF12, Multiple EGF-like domains protein 12, Multiple epidermal growth factor-like domains protein 12, Platelet endothelial aggregation receptor 1
Molecular Weight 110666 Da
Gene ID 375033
NCBI Accession NP_001073940
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Johnson, Yanek, Chen et al.: "Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists." in: Nature genetics, Vol. 42, Issue 7, pp. 608-13, 2010 (PubMed).

Jones, Bray, Garner et al.: "A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways." in: Blood, Vol. 114, Issue 7, pp. 1405-16, 2009 (PubMed).

Herrera-Galeano, Becker, Wilson et al.: "A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 8, pp. 1484-90, 2008 (PubMed).

Nanda, Bao, Lin et al.: "Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24680-9, 2005 (PubMed).

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