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phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) (AA 646-676), (C-Term) antibody

Details for Product No. ABIN954143, Supplier: Log in to see
Antigen
  • BCAP
  • RP11-34E5.3
  • 1810044J04Rik
Epitope
C-Term, AA 646-676
17
15
5
2
2
1
1
1
1
1
1
1
Reactivity
Human
70
18
15
Host
Rabbit
41
34
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
50
25
20
16
11
8
6
2
1
1
1
1
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 646-676aa) of human PIK3AP1.
Isotype Ig
Specificity This antibody recognizes PIK3AP1 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name PIK3AP1 (PIK3AP1 Antibody Abstract)
Background PIK3AP1 is involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. It couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. PIK3AP1 seems to have a complementary role with CD19 in PI3K activation (By similarity) and is may be involved in the survival of mature B cells via activation of REL (By similarity).Synonyms: B-cell adapter for phosphoinositide 3-kinase, BCAP, Phosphoinositide 3-kinase adapter protein 1
Gene ID 118788
NCBI Accession NP_689522
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) (AA 646-676), (C-Term) antibody (ABIN954143) Western blot analysis in A549 cell line lysates (35ug/lane) using PIK3AP1  Antibody  ...
Background publications Koutros, Schumacher, Hayes et al.: "Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer." in: Cancer research, Vol. 70, Issue 6, pp. 2389-96, 2010 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Maruoka, Suzuki, Kawata et al.: "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases." in: FEBS letters, Vol. 579, Issue 14, pp. 2986-90, 2005 (PubMed).

Okada, Maeda, Iwamatsu et al.: "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation." in: Immunity, Vol. 13, Issue 6, pp. 817-27, 2001 (PubMed).