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Details for Product No. ABIN954233

Protein O-Fucosyltransferase 2 (POFUT2) (AA 235-265), (Middle Region) antibody

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Synonyms FUT13, C21orf80, 2310011G23Rik, AI256847, BC003494, fc46a11, wu:fc46a11, zgc:194822
»Alternatives AA 235-265, Middle Region
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN954233
Quantity 0.4 mL
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 235-265 amino acids from the Central region of human POFUT2
Specificity This antibody recognizes Human POFUT2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name POFUT2
Background Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF, MIM 131530)-like repeats or thrombospondin (THBS, see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857].
Alternate names: C21orf80, FUT13, GDP-fucose protein O-fucosyltransferase 2, KIAA0958, O-FucT-2, Peptide- O-fucosyltransferase 2
Molecular Weight 49976 Da
Gene ID 23275
NCBI Accession NP_056042
Research Area Signaling, Metabolism, Organelles
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Menzel, Vellai, Takacs-Vellai et al.: "The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development." in: Genomics, Vol. 84, Issue 2, pp. 320-30, 2004 (PubMed).

Luo, Koles, Vorndam et al.: "Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9393-9, 2006 (PubMed).

Luo, Nita-Lazar, Haltiwanger: "Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9385-92, 2006 (PubMed).

Feng, Zhu: "Genome-wide searching of rare genetic variants in WTCCC data." in: Human genetics, Vol. 128, Issue 3, pp. 269-80, 2010 (PubMed).

Alternatives for antigen "Protein O-Fucosyltransferase 2 (POFUT2)", type "Antibodies"
Hosts (17), (4)
Reactivities (18), (7), (3), (1), (1), (1)
Applications (15), (10), (8), (3), (2), (1)
Epitopes (3), (2), (2), (1), (1), (1)