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Protein O-Fucosyltransferase 2 (POFUT2) (AA 235-265), (Middle Region) antibody

Details for Product No. ABIN954233, Supplier: Log in to see
Antigen
  • C21orf80
  • FUT13
  • fc46a11
  • wu:fc46a11
  • zgc:194822
  • 2310011G23Rik
  • AI256847
  • BC003494
Epitope
AA 235-265, Middle Region
15
13
11
3
3
2
1
Reactivity
Human
44
10
6
1
1
1
Host
Rabbit
36
8
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
36
23
22
6
3
Supplier
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Immunogen KLH conjugated synthetic peptide between 235-265 amino acids from the Central region of human POFUT2
Isotype Ig
Specificity This antibody recognizes Human POFUT2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name POFUT2 (POFUT2 Antibody Abstract)
Background Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF, MIM 131530)-like repeats or thrombospondin (THBS, see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857].Synonyms: C21orf80, FUT13, GDP-fucose protein O-fucosyltransferase 2, KIAA0958, O-FucT-2, Peptide-O-fucosyltransferase 2
Molecular Weight 49976 Da
Gene ID 23275
NCBI Accession NP_056042
Research Area Signaling, Metabolism, Organelles
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Protein O-Fucosyltransferase 2 (POFUT2) (AA 235-265), (Middle Region) antibody (ABIN954233) Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tis...
Western Blotting (WB) image for anti-Protein O-Fucosyltransferase 2 (POFUT2) (AA 235-265), (Middle Region) antibody (ABIN954233) Western blot analysis of POFUT2 Antibody (Center) in HepG2 cell line lysates (35ug/la...
Background publications Feng, Zhu: "Genome-wide searching of rare genetic variants in WTCCC data." in: Human genetics, Vol. 128, Issue 3, pp. 269-80, 2010 (PubMed).

Luo, Nita-Lazar, Haltiwanger: "Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9385-92, 2006 (PubMed).

Luo, Koles, Vorndam et al.: "Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9393-9, 2006 (PubMed).

Menzel, Vellai, Takacs-Vellai et al.: "The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development." in: Genomics, Vol. 84, Issue 2, pp. 320-30, 2004 (PubMed).