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Ring Finger Protein 34 (RNF34) (AA 282-311), (C-Term) antibody

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Synonyms rnf34, AW061037, AW536122, BC004042, C88279, RIFF, CARP-1, CARP1, RFI, RIF, hRFI, Momo
C-Term, AA 282-311
(24), (18), (16), (15), (14), (3), (2), (2), (1)
(83), (20), (18), (15), (13), (2), (2), (2), (2), (2), (2), (1), (1), (1)
(48), (35), (3)
(4), (4), (4), (4), (4), (3), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(59), (49), (21), (11), (7), (5), (2)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 282-311 amino acids from the C-terminal region of human RNF34
Isotype Ig
Specificity This antibody reacts to RNF34.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name RFI / RNF34 (RNF34 Antibody Abstract)
Background The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.Synonyms: CARP-1, CARP1, Caspases-8 and -10-associated RING finger protein 1, E3 ubiquitin-protein ligase RNF34, FYVE-RING finger protein Momo, Human RING finger homologous to inhibitor of apoptosis protein, RIFF
Molecular Weight 41641 Da
Gene ID 80196
NCBI Accession NP_079402
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Ring Finger Protein 34 (RNF34) (AA 282-311), (C-Term) antibody (ABIN954520) RNF34 Antibody (C-term) western blot analysis in Hela cell line lysates (35µg/lane).T...
Background publications Grunda, Fiveash, Palmer et al.: "Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 10, pp. 2890-8, 2010 (PubMed).

Yang, Dicker, Chen et al.: "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 5, pp. 670-82, 2008 (PubMed).

Yang, Rozan, McDonald et al.: "CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 3273-81, 2007 (PubMed).

Konishi, Sasaki, Watanabe et al.: "Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells." in: Molecular cancer therapeutics, Vol. 4, Issue 5, pp. 743-50, 2005 (PubMed).

Sasaki, Watanabe, Konishi et al.: "Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence." in: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 3, pp. 507-12, 2004 (PubMed).

Catalog No. ABIN954520
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