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Sterol Carrier Protein 2 (SCP2) (AA 13-43), (N-Term) antibody

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Synonyms AI586070, D10Ertd73e, OS-4, OS4, SCP2, PLTP, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX, NSLIPTR, SCPx, AA409774, AA409893, C76618, C79031, ns-LTP
AA 13-43, N-Term
(31), (19), (15), (11), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(122), (27), (25), (4), (3), (3), (2), (1), (1)
(88), (19), (15)
(9), (9), (9), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(82), (66), (47), (15), (11), (4), (3), (2)
Pubmed 5 references available
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Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 13-43 amino acids from the N-terminal region of Human SCP2 Genename: SCP2
Isotype Ig
Specificity Recognizes SCP2 (N-term).
Purification Protein A column followed by peptide Affinity purification
Alternative Name SCP2 / SCPX (SCP2 Antibody Abstract)
Background This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.Synonyms: NSL-TP, Non-specific lipid-transfer protein, Propanoyl-CoA C-acyltransferase, SCP-2, SCP-X, SCP-chi, Sterol carrier protein 2, Sterol carrier protein X
Gene ID 6342
NCBI Accession NP_001007100
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Sterol Carrier Protein 2 (SCP2) (AA 13-43), (N-Term) antibody (ABIN954693) Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human liver tissue...
Western Blotting (WB) image for anti-Sterol Carrier Protein 2 (SCP2) (AA 13-43), (N-Term) antibody (ABIN954693) Western blot analysis of SCP2 Antibody (N-term) Cat.-No AP53816PU-N in T47D cell line...
Background publications Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Dansen, Kops, Denis et al.: "Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a." in: Journal of lipid research, Vol. 45, Issue 1, pp. 81-8, 2004 (PubMed).

Catalog No. ABIN954693
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