Aralkylamine N-Acetyltransferase (AANAT) (N-Term), (AA 33-63) antibody

Details for Product No. ABIN954733
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Antigen
Synonyms DSPS, SNAT, AA-NAT, Nat4, Nat-2, Snat
Epitope
N-Term, AA 33-63
(14), (7), (5), (2), (2), (2), (2)
Reactivity
Human
(44), (31), (27), (24), (12), (12), (6), (1), (1), (1), (1)
Host
Rabbit
(48)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(30), (20), (10), (8), (6), (5), (2)
Pubmed 2 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN954733
357.50 $
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Immunogen KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human AANAT
Isotype Ig
Specificity This antibody reacts to Serotonin acetylase.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name Serotonin Acetylase
Background AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.Synonyms: AA-NAT, AANAT, Aralkylamine N-acetyltransferase, SNAT, Serotonin N-acetyltransferase
Gene ID 15
NCBI Accession NP_001079
Research Area Enzymes
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Gratacòs, Costas, de Cid et al.: "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 150B, Issue 6, pp. 808-16, 2009 (PubMed).

Mansour, Talkowski, Wood et al.: "Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia." in: Bipolar disorders, Vol. 11, Issue 7, pp. 701-10, 2009 (PubMed).

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