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Details for Product No. ABIN955037

Syntaxin 1A (Brain) (STX1A) (N-Term), (AA 36-65) antibody

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Antigen
Synonyms
HPC-1, P35-1, STX1, SYN1A, CG10716, CG18615, CG31136, CG5448, CT30033, Dm Syx1, DmSyx1A, Dmel\\CG31136, SYX1A, Syt1A, Syx, Syx-1A, Syx1, Syx1a, SyxA, anon-EST:Gibbs4, anon-WO02059370.54, dSyx1, l(3)06 ... show more
Epitope
»Alternatives N-Term, AA 36-65
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN955037
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 36~65 amino acids from the N-terminal region of Human STX1A Genename: STX1A
Specificity This antibody recognizes Human Syntaxin 1A / STX1A (N-term).
Purification Affinity Chromatography on Protein A
Alternative Name Syntaxin 1A / STX1A
Background This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system- specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis.
Alternate names: Neuron-specific antigen HPC-1, STX1, Syntaxin-1A
Molecular Weight 33023 Da
Gene ID 6804
NCBI Accession NP_001159375
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Tian, Das, Sheng: "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 26265-74, 2003 (PubMed).

Ramakrishnan, Drescher, Drescher: "Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3." in: The Journal of biological chemistry, Vol. 284, Issue 3, pp. 1364-72, 2009 (PubMed).

Chen, Nelson, Khauv et al.: "Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis." in: The Journal of biological chemistry, Vol. 284, Issue 11, pp. 6877-84, 2009 (PubMed).

Corominas, Ribasés, Cuenca-León et al.: "Contribution of syntaxin 1A to the genetic susceptibility to migraine: a case-control association study in the Spanish population." in: Neuroscience letters, Vol. 455, Issue 2, pp. 105-9, 2009 (PubMed).

Hamdan, Piton, Gauthier et al.: "De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy." in: Annals of neurology, Vol. 65, Issue 6, pp. 748-53, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with chronic kidney disease in individuals with different lipid profiles." in: International journal of molecular medicine, Vol. 24, Issue 2, pp. 233-46, 2009 (PubMed).

Alternatives for antigen "Syntaxin 1A (Brain) (STX1A)", type "Antibodies"
Hosts (84), (22), (1)
Reactivities (93), (64), (63), (38), (38), (24), (12), (12), (5), (1), (1), (1)
Applications (60), (34), (31), (30), (14), (12), (6), (4), (3), (3), (3), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (18), (16), (12), (7), (2), (2), (1), (1)
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