Taste Receptor, Type 1, Member 1 (TAS1R1) (AA 322-351), (Middle Region) antibody

Details for Product No. ABIN955080
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Antigen
Synonyms GPR70, T1R1, TR1, Gpr70, T1r1
Epitope
AA 322-351, Middle Region
(12), (7), (7), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(48), (16), (15), (2)
Host
Rabbit
(54), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(29), (20), (14), (13), (9), (8), (1), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN955080
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Immunogen KLH conjugated synthetic peptide between 322-351 amino acids from the Central region of human TAS1R1
Isotype Ig
Specificity This antibody reacts to TAS1R1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name TAS1R1 / GPR70
Background The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: G-protein coupled receptor 70, GM148, TR1, Taste receptor T1R1, Taste receptor type 1 member 1
Molecular Weight 93074 Da
Gene ID 80835
NCBI Accession NP_619642
Research Area Signaling, Receptors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Fushan, Simons, Slack et al.: "Association between common variation in genes encoding sweet taste signaling components and human sucrose perception." in: Chemical senses, Vol. 35, Issue 7, pp. 579-92, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

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