TGFB-Induced Factor Homeobox 2 (TGIF2) (C-Term), (AA 170-199) antibody

Details for Product No. ABIN955180
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Antigen
Synonyms xtgif2, MGC81646, TGIF2, 4921501K24, 5730599O09Rik, C80753, C81206, RGD1561562, RGD1561975, Tgif2, Tgif2l2
Epitope
C-Term, AA 170-199
(13), (9), (8), (7), (7), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(52), (3), (2), (2)
Host
Rabbit
(36), (14), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(54), (41), (9), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN955180
357.50 $
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Immunogen KLH conjugated synthetic peptide between 170-199 amino acids from the C-terminal region of human TGIF2
Specificity This antibody detects TGIF2 (C-term).
Purification Protein A column followed by peptide affinity purification
Alternative Name TGIF2
Background The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.
Alternate names: 5'-TG-3'-interacting factor 2, Homeobox protein TGIF2, TGF(beta)-induced transcription factor 2, TGFB-induced factor 2
Gene ID 60436
NCBI Accession NP_001186442
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Imoto, Pimkhaokham, Watanabe et al.: "Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines." in: Biochemical and biophysical research communications, Vol. 276, Issue 1, pp. 264-70, 2000 (PubMed).

Melhuish, Gallo, Wotton: "TGIF2 interacts with histone deacetylase 1 and represses transcription." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32109-14, 2001 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Watanabe, Imoto, Katahira et al.: "Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers." in: Japanese journal of cancer research : Gann, Vol. 93, Issue 10, pp. 1114-22, 2002 (PubMed).

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