TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) (AA 58-88), (N-Term) antibody

Details for Product No. ABIN955209
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms TIFA, xtifa, T2BP, T6BP, TIFAA, T2bp, Ab2-389
Epitope
N-Term, AA 58-88
(15), (15), (1)
Reactivity
Human
(29)
Host
Rabbit
(29)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(19), (12), (10), (3), (3)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen KLH conjugated synthetic peptide between 58~88 amino acids from the N-terminal region of human TIFA
Isotype Ig
Specificity This antibody detects TIFA / T2BP (N-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name TIFA / T2BP (TIFA Antibody Abstract)
Background Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.Synonyms: Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF-interacting protein with FHA domain-containing protein A, TRAF2-binding protein
Gene ID 92610
NCBI Accession NP_443096
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Background publications Minoda, Saeki, Aki et al.: "A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling." in: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 1023-30, 2006 (PubMed).

Ea, Sun, Inoue et al.: "TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 43, pp. 15318-23, 2004 (PubMed).

Zhang, Palmer, Abbott et al.: "CpG ODN 2006 and IL-12 are comparable for priming Th1 lymphocyte and IgG responses in cattle immunized with a rickettsial outer membrane protein in alum." in: Vaccine, Vol. 21, Issue 23, pp. 3307-18, 2003 (PubMed).

Takatsuna, Kato, Gohda et al.: "Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor ..." in: The Journal of biological chemistry, Vol. 278, Issue 14, pp. 12144-50, 2003 (PubMed).

Validation Images
Catalog No. ABIN955209
357.50 $
Plus shipping costs $45.00
Quantity
Price
0.4 mL
357.50 $

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?