TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA) (N-Term), (AA 58-88) antibody

Details for Product No. ABIN955209
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Antigen
Synonyms TIFA, xtifa, T2BP, T6BP, TIFAA, T2bp, Ab2-389
Epitope
N-Term, AA 58-88
(8), (7), (2), (1)
Reactivity
Human
(23)
Host
Rabbit
(23)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(12), (10), (8), (3)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN955209
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Immunogen KLH conjugated synthetic peptide between 58~88 amino acids from the N-terminal region of human TIFA
Isotype Ig
Specificity This antibody detects TIFA / T2BP (N-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name TIFA / T2BP
Background Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.Synonyms: Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF-interacting protein with FHA domain-containing protein A, TRAF2-binding protein
Gene ID 92610
NCBI Accession NP_443096
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Background publications Takatsuna, Kato, Gohda et al.: "Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling." in: The Journal of biological chemistry, Vol. 278, Issue 14, pp. 12144-50, 2003 (PubMed).

Zhang, Palmer, Abbott et al.: "CpG ODN 2006 and IL-12 are comparable for priming Th1 lymphocyte and IgG responses in cattle immunized with a rickettsial outer membrane protein in alum." in: Vaccine, Vol. 21, Issue 23, pp. 3307-18, 2003 (PubMed).

Ea, Sun, Inoue et al.: "TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 43, pp. 15318-23, 2004 (PubMed).

Minoda, Saeki, Aki et al.: "A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling." in: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 1023-30, 2006 (PubMed).

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