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Tolloid-Like 2 (TLL2) (AA 305-336), (Middle Region) antibody

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  • MGC97633
  • RGD1559756
  • TLL2
  • Xld
  • xolloid
AA 305-336, Middle Region
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Immunogen KLH conjugated synthetic peptide between 305-336 amino acids from the Central region of human TLL2
Isotype Ig
Specificity This antiboidy detects TLL2 (Center).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name TLL2 (TLL2 Antibody Abstract)
Background This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.Synonyms: KIAA0932, Tolloid-like protein 2
Gene ID 7093
NCBI Accession NP_036597
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tolloid-Like 2 (TLL2) (AA 305-336), (Middle Region) antibody (ABIN955234) TLL2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin e...
Western Blotting (WB) image for anti-Tolloid-Like 2 (TLL2) (AA 305-336), (Middle Region) antibody (ABIN955234) TLL2 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane...
Background publications Mac Sweeney, Gil-Parrado, Vinzenz, Bernardi, Hein, Bodendorf, Erbel, Logel, Gerhartz: "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases." in: Journal of molecular biology, Vol. 384, Issue 1, pp. 228-39, 2008

Lesch, Timmesfeld, Renner, Halperin, Röser, Nguyen, Craig, Romanos, Heine, Meyer, Freitag, Warnke, Romanos, Schäfer, Walitza, Reif, Stephan, Jacob: "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 115, Issue 11, pp. 1573-85, 2008

Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005

Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004

Uzel, Scott, Babakhanlou-Chase, Palamakumbura, Pappano, Hong, Greenspan, Trackman: "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 22537-43, 2001