Tropomodulin 1 (TMOD1) (AA 169-198), (Middle Region) antibody

Details for Product No. ABIN955335
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Antigen
Synonyms tropomodulin-1, TMOD1, si:ch211-288h2.6, D9S57E, ETMOD, TMOD, E-Tmod, Tmod
Epitope
AA 169-198, Middle Region
(7), (6), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(29), (4), (4), (1), (1)
Host
Rabbit
(15), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(30), (12), (11), (8), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN955335
357.50 $
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Immunogen KLH conjugated synthetic peptide between 169-198 amino acids from the Central region of human TMOD1
Specificity This antibody detects Tropomodulin-1 (TMOD1) (Center).
Purification Protein A column followed by peptide affinity purification
Alternative Name Tropomodulin-1 (TMOD1)
Background TMOD1 is a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene.
Alternate names: D9S57E, E-Tmod, Erythrocyte tropomodulin, TMOD
Gene ID 7111
NCBI Accession NP_001159588
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Rho, Chun, Lee et al.: "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture." in: FEBS letters, Vol. 557, Issue 1-3, pp. 57-63, 2004 (PubMed).

Pawlak, McGarvey, Nguyen et al.: "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder." in: International journal of cancer. Journal international du cancer, Vol. 110, Issue 3, pp. 368-73, 2004 (PubMed).

Vera, Lao, Hamelberg et al.: "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction." in: Archives of biochemistry and biophysics, Vol. 444, Issue 2, pp. 130-8, 2005 (PubMed).

Kong, Kedes: "Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9589-99, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

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