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Ubiquitin Specific Peptidase 12 (USP12) (AA 221-251), (Middle Region) antibody

Details for Product No. ABIN955485, Supplier: Log in to see
Antigen
  • hapln3
  • USP12P1
  • usp12
  • Ubh1
  • ubh1
  • usp12l1
  • UBH1
  • USP12L1
  • USP12
  • sb:eu882
  • wu:fi09d12
Epitope
AA 221-251, Middle Region
21
15
15
14
9
4
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
55
26
6
1
1
1
1
1
Host
Rabbit
64
7
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
6
6
6
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
64
49
16
3
2
Supplier
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Immunogen KLH conjugated synthetic peptide between 221-251 amino acids from the Central region of human USP12
Isotype Ig
Specificity This antibody detects USP12 (Center).
Cross-Reactivity (Details) Species reactivity (expected):Bovine, Xenopus.
Species reactivity (tested):Human, Mouse.
Purification Protein A column followed by peptide affinity purification
Alternative Name USP12 (USP12 Antibody Abstract)
Background USP12is a deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.Synonyms: Deubiquitinating enzyme 12, UBH1, USP12L1, Ubiquitin carboxyl-terminal hydrolase 12, Ubiquitin thioesterase 12, Ubiquitin-hydrolyzing enzyme 1, Ubiquitin-specific-processing protease 12
Gene ID 219333
NCBI Accession NP_872294
Research Area Proteolysis / Ubiquitin
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin Specific Peptidase 12 (USP12) (AA 221-251), (Middle Region) antibody (ABIN955485) USP12 Antibody (Center) western blot analysis in A375 cell line lysates (35 µg/lane)....
Western Blotting (WB) image for anti-Ubiquitin Specific Peptidase 12 (USP12) (AA 221-251), (Middle Region) antibody (ABIN955485) USP12 Antibody (Center) western blot analysis in mouse bladder tissue lysates (35 µg/...
Background publications Kee, Yang, Cohn et al.: "WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex." in: The Journal of biological chemistry, Vol. 285, Issue 15, pp. 11252-7, 2010 (PubMed).

Asano, Matsushita, Umeno et al.: "A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population." in: Nature genetics, Vol. 41, Issue 12, pp. 1325-9, 2009 (PubMed).

Cohn, Kee, Haas et al.: "UAF1 is a subunit of multiple deubiquitinating enzyme complexes." in: The Journal of biological chemistry, Vol. 284, Issue 8, pp. 5343-51, 2009 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13. ..." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

Puente, Sánchez, Overall et al.: "Human and mouse proteases: a comparative genomic approach." in: Nature reviews. Genetics, Vol. 4, Issue 7, pp. 544-58, 2003 (PubMed).