WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2) (C-Term), (AA 422-451) antibody

Details for Product No. ABIN955579
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Antigen
Synonyms ATG18B, Atg21, WIPI-2, 1110018O08Rik, 2510001I10Rik
Epitope
C-Term, AA 422-451
(15), (8), (7), (7), (2), (1)
Reactivity
Human, Mouse (Murine)
(30), (7), (2)
Host
Rabbit
(29), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(30), (19), (8), (4), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN955579
357.50 $
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Immunogen KLH conjugated synthetic peptide between 422~451 amino acids from the C-terminal region of human WIPI2
Isotype Ig
Specificity This antibody detects WIPI-2 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Protein A column followed by peptide affinity purification
Alternative Name WIPI-2
Background WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).Synonyms: CGI-50, WD repeat domain phosphoinositide-interacting protein 2, WIPI2, WIPI49-like protein 2
Gene ID 26100
NCBI Accession NP_001028690
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Background publications Simpson, Wellenreuther, Poustka et al.: "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing." in: EMBO reports, Vol. 1, Issue 3, pp. 287-92, 2001 (PubMed).

Proikas-Cezanne, Waddell, Gaugel et al.: "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." in: Oncogene, Vol. 23, Issue 58, pp. 9314-25, 2004 (PubMed).

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