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alpha 2 Macroglobulin antibody (C-Term)

A2M Reactivity: Human IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN965491
  • Target See all alpha 2 Macroglobulin (A2M) Antibodies
    alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
    Binding Specificity
    • 13
    • 11
    • 9
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 108
    • 23
    • 20
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 106
    • 18
    • 15
    • 6
    • 1
    • 1
    Rabbit
    Clonality
    • 123
    • 22
    Polyclonal
    Conjugate
    • 77
    • 21
    • 14
    • 9
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This alpha 2 Macroglobulin antibody is un-conjugated
    Application
    • 90
    • 59
    • 37
    • 19
    • 14
    • 9
    • 9
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Immunohistochemistry (IHC)
    Purification
    Purified by antigen-specific affinity chromatography.
    Immunogen
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human A2M (Alpha-2-macroglobulin precursor)
    Top Product
    Discover our top product A2M Primary Antibody
  • Application Notes
    ELISA, Western blotting: 1µg/ml for 2hrs.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    This antibody is stored in PBS, 50% glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Bishop, Bell: "Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter." in: Cell, Vol. 42, Issue 1, pp. 51-60, (1985) (PubMed).

  • Target
    alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
    Alternative Name
    A2M (A2M Products)
    Synonyms
    A2MD antibody, CPAMD5 antibody, FWP007 antibody, S863-7 antibody, A2MAC1 antibody, A2m1 antibody, A2maa antibody, Mam antibody, A2mp antibody, A2M antibody, LOC733429 antibody, endod antibody, cpamd5 antibody, fwp007 antibody, s863-7 antibody, a2mb antibody, endodermin antibody, Alpha-2-M antibody, alpha-2-macroglobulin antibody, pregnancy-zone protein L homeolog antibody, alpha-2-macroglobulin S homeolog antibody, pregnancy zone protein antibody, alpha-2-macroglobulin-like antibody, A2M antibody, A2m antibody, LOC477699 antibody, pzp.L antibody, AZL_c00450 antibody, LOC100349077 antibody, a2m antibody, LOC100061656 antibody, LOC100090399 antibody, a2m.S antibody, LOC100469973 antibody, LOC100595735 antibody, PZP antibody, LOC100353095 antibody, LOC101122940 antibody, LOC101801552 antibody, LOC100911545 antibody
    Background
    A2M(Alpha-2-macroglobulin is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the `bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
    Pathways
    Lipid Metabolism
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