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Details for Product No. ABIN965491

alpha-2-Macroglobulin (A2M) (C-Term) antibody

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Antigen
Synonyms A2MD, CPAMD5, FWP007, S863-7, A2MAC1, A2m1, A2maa, Mam, A2mp, A2M, LOC733429, LOC100221148, LOC100224071, endod, cpamd5, fwp007, s863-7, a2mb, endodermin
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN965491
Quantity 0.1 mg
Price
288.75 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human A2M (Alpha-2-macroglobulin precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name A2M
Background A2M(Alpha-2-macroglobulin is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the `bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Matthijs, Devriendt, Cassiman et al.: "Structure of the human alpha-2 macroglobulin gene and its promotor." in: Biochemical and biophysical research communications, Vol. 184, Issue 2, pp. 596-603, 1992 (PubMed).

Bishop, Bell: "Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter." in: Cell, Vol. 42, Issue 1, pp. 51-60, 1985 (PubMed).

Sottrup-Jensen, Stepanik, Kristensen et al.: "Primary structure of human alpha 2-macroglobulin. V. The complete structure." in: The Journal of biological chemistry, Vol. 259, Issue 13, pp. 8318-27, 1984 (PubMed).

Zhang, Li, Martin et al.: "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." in: Nature biotechnology, Vol. 21, Issue 6, pp. 660-6, 2003 (PubMed).

Alternatives for antigen "alpha-2-Macroglobulin (A2M)", type "Antibodies"
Hosts (66), (58), (39), (12), (6), (2)
Reactivities (155), (24), (24), (16), (13), (12), (4), (2), (1), (1)
Applications (116), (97), (33), (27), (20), (14), (11), (10), (8), (8), (8), (7), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Conjugates (18), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (7), (5), (2), (2), (2), (2), (2), (2)
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