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Adiponectin antibody (Adiponectin, C1Q and Collagen Domain Containing) (AA 55-69)

Details for Product anti-ADIPOQ Antibody No. ABIN965514, Supplier: Log in to see
Antigen
  • MGC84292
  • ADIPOQ
  • APM1
  • ACDC
  • ACRP30
  • ADIPQTL1
  • ADPN
  • APM-1
  • GBP28
  • 30kDa
  • APN
  • Acdc
  • Acrp30
  • adipo
  • apM1
  • ADN
Alternatives
anti-Human Adiponectin antibody for Western Blotting
Epitope
AA 55-69, N-Term
54
31
27
13
12
11
10
10
7
6
6
6
5
5
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
447
145
97
30
12
4
4
2
1
Host
Rabbit
357
223
16
11
4
3
Clonality
Polyclonal
Conjugate
This Adiponectin antibody is un-conjugated
69
27
23
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
396
364
85
46
45
35
14
12
11
10
9
9
8
2
2
2
2
2
1
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to residues 55-69 of human ADIPOQ(Adiponectin precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ADIPOQ (ADIPOQ Antibody Abstract)
Background ADIPOQ (Adiponectin) is an important negative regulator in hematopoiesis and immunesystems. ADIPOQ may be involved in ending inflammatory responses through its inhibitory functions. ADIPOQ inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It inhibits TNF-alpha-induced expression of endothelial adhesion molecules. ADIPOQ is involved in the control of fat metabolism and insulin sensitivity. Defects in ADIPOQ are the cause of adiponectin deficiency. The result is a very low concentration of plasma adiponectin. The decreased adiponectin plasma levels are associated with obesity insulin resistance, and diabetes type 2.
Pathways AMPK Signaling
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Schäffler, Orsó, Palitzsch et al.: "The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for ..." in: Biochemical and biophysical research communications, Vol. 260, Issue 2, pp. 416-25, 1999 (PubMed).

Saito, Tobe, Minoshima et al.: "Organization of the gene for gelatin-binding protein (GBP28)." in: Gene, Vol. 229, Issue 1-2, pp. 67-73, 1999 (PubMed).

Arita, Kihara, Ouchi et al.: "Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity." in: Biochemical and biophysical research communications, Vol. 257, Issue 1, pp. 79-83, 1999 (PubMed).

Background publications Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).

Yamauchi, Kamon, Waki et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. ..." in: Nature medicine, Vol. 7, Issue 8, pp. 941-6, 2001 (PubMed).

Ouchi, Kihara, Arita et al.: "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway." in: Circulation, Vol. 102, Issue 11, pp. 1296-301, 2000 (PubMed).

Yokota, Oritani, Takahashi et al.: "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages." in: Blood, Vol. 96, Issue 5, pp. 1723-32, 2000 (PubMed).

Nakano, Tobe, Choi-Miura et al.: "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma." in: Journal of biochemistry, Vol. 120, Issue 4, pp. 803-12, 1997 (PubMed).

Berg, Egner, Lowe: "Mechanism of F factor-enhanced excision of transposon Tn5." in: Gene, Vol. 22, Issue 1, pp. 1-7, 1983 (PubMed).