Aquaporin 2 (Collecting Duct) (AQP2) (N-Term) antibody

Details for Product No. ABIN965586
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Antigen
Synonyms AQP-CD, WCH-CD, cph, jpk, AQP-2, aquaporin-2
Epitope
N-Term
(35), (32), (24), (19), (15), (12), (12), (7), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(134), (123), (123), (12), (11), (8), (4), (2), (1), (1)
Host
Rabbit
(174), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (9), (6), (5), (5), (5), (5), (5), (5), (5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(100), (55), (50), (48), (33), (24), (21), (21), (6), (2), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name AQP2 (AQP2 Antibody Abstract)
Background The AQP2(aquaporin 2)is a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. In collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent and phosphorylation of Ser-256 is necessary for expression of AQP2 in the apical membrane. The changes in urinary excretion of aquaporin-2 indicates circulatory blood volume depletion, and estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in patients with diabetic ketoacidosis
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Hirano, Zuber, Roth et al.: "The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus." in: The American journal of pathology, Vol. 163, Issue 1, pp. 111-20, 2003 (PubMed).

Ogura, Morita, Takeuchi et al.: "Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia." in: Hormone research, Vol. 59, Issue 1, pp. 30-4, 2003 (PubMed).

van Balkom, Savelkoul, Markovich et al.: "The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41473-9, 2002 (PubMed).

Marr, Bichet, Hoefs et al.: "Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus." in: Journal of the American Society of Nephrology : JASN, Vol. 13, Issue 9, pp. 2267-77, 2002 (PubMed).

Lin, Bichet, Sasaki et al.: "Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 6, pp. 2694-700, 2002 (PubMed).

Kusaka, Saito, Nakamura et al.: "Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis." in: Nephron, Vol. 91, Issue 1, pp. 167-9, 2002 (PubMed).

Marr, Bichet, Lonergan et al.: "Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus." in: Human molecular genetics, Vol. 11, Issue 7, pp. 779-89, 2002 (PubMed).

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Catalog No. ABIN965586
302.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
302.50 $

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