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Aquaporin 2 (Collecting Duct) (AQP2) (N-Term) antibody

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Antigen
Synonyms AQP-CD, WCH-CD, cph, jpk, AQP-2, aquaporin-2, AQP2
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN965586
Quantity 0.1mg
Price
288.75 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)
Purification Purified by antigen-specific affinity chromatography.

Target Details

Application Details Handling References Alternatives back to top
Alternative Name AQP2
Background The AQP2(aquaporin 2)is a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. In collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent and phosphorylation of Ser-256 is necessary for expression of AQP2 in the apical membrane. The changes in urinary excretion of aquaporin-2 indicates circulatory blood volume depletion, and estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in patients with diabetic ketoacidosis

Application Details

Target Details Handling References Alternatives back to top
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Buffer This antibody is stored in PBS, 50% glycerol
Preservative 0.01% Sodium Azide
Storage -20 °C

References

Target Details Application Details Handling Alternatives back to top
Product cited in: Marr, Bichet, Hoefs et al.: "Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus." in: Journal of the American Society of Nephrology : JASN, Vol. 13, Issue 9, pp. 2267-77, 2002 (PubMed).

van Balkom, Savelkoul, Markovich et al.: "The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41473-9, 2002 (PubMed).

Hirano, Zuber, Roth et al.: "The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus." in: The American journal of pathology, Vol. 163, Issue 1, pp. 111-20, 2003 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Aquaporin 2 (Collecting Duct) (AQP2)", type "Antibodies"
Hosts (151), (1)
Reactivities (127), (110), (108), (91), (75), (67), (55), (51), (1)
Applications (98), (50), (42), (30), (21), (18), (15), (5), (3), (1)
Conjugates (10), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (24), (20), (20), (17), (16), (11), (8), (4), (3), (1), (1), (1), (1)
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