Aquaporin 2 (Collecting Duct) (AQP2) (N-Term) antibody

Details for Product No. ABIN965586
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Antigen
Synonyms AQP-CD, WCH-CD, cph, jpk, AQP-2, aquaporin-2
Epitope
N-Term
(33), (28), (19), (17), (11), (10), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(113), (108), (103), (79), (68), (59), (52), (2), (2), (1)
Host
Rabbit
(148), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1)
Application
ELISA, Western Blotting (WB)
(69), (60), (36), (25), (24), (14), (10), (4), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN965586
302.50 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name AQP2
Background The AQP2(aquaporin 2)is a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. In collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent and phosphorylation of Ser-256 is necessary for expression of AQP2 in the apical membrane. The changes in urinary excretion of aquaporin-2 indicates circulatory blood volume depletion, and estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in patients with diabetic ketoacidosis
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Hirano, Zuber, Roth et al.: "The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus." in: The American journal of pathology, Vol. 163, Issue 1, pp. 111-20, 2003 (PubMed).

van Balkom, Savelkoul, Markovich et al.: "The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41473-9, 2002 (PubMed).

Marr, Bichet, Hoefs et al.: "Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus." in: Journal of the American Society of Nephrology : JASN, Vol. 13, Issue 9, pp. 2267-77, 2002 (PubMed).

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