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Aquaporin 2 (Collecting Duct) (AQP2) (N-Term) antibody

Antigen

Aquaporin 2 (Collecting Duct) (AQP2)
Synonyms AQP-CD, WCH-CD, MGC34501, cph, jpk, AQP-2, MGC156502, aquaporin-2, AQP2
Binding Site
Alternatives

N-Term
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA, Western Blotting (WB)
3 references available
Catalog no. ABIN965586
Quantity 0.1mg
Price 288.75 $   Plus shipping costs $45.00
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Additional Information
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Alternative name AQP2
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)
Description The AQP2(aquaporin 2)is a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. In collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent and phosphorylation of Ser-256 is necessary for expression of AQP2 in the apical membrane. The changes in urinary excretion of aquaporin-2 indicates circulatory blood volume depletion, and estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in patients with diabetic ketoacidosis

Application Details
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Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Purification Purified by antigen-specific affinity chromatography.
Buffer This antibody is stored in PBS, 50% glycerol
Preservative 0.01% Sodium Azide
Storage Store at -20°C.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Marr, Bichet, Hoefs et al.: "Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus." in: Journal of the American Society of Nephrology : JASN, Vol. 13, Issue 9, pp. 2267-77, 2002 (PubMed).

van Balkom, Savelkoul, Markovich et al.: "The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41473-9, 2002 (PubMed).

Hirano, Zuber, Roth et al.: "The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus." in: The American journal of pathology, Vol. 163, Issue 1, pp. 111-20, 2003 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Aquaporin 2 (Collecting Duct) (AQP2)", type "Antibodies"
Hosts Rabbit (107), Goat (1)
Reactivities Mouse (Murine) (85), Human (78), Rat (Rattus) (70), Dog (Canine) (54), Cow (Bovine) (37), Pig (Porcine) (32), Chicken (30), Sheep (Ovine) (28), Monkey (1)
Applications Immunofluorescence (IF) (66), Western Blotting (WB) (35), Flow Cytometry (FACS) (30), ELISA (24), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunohistochemistry (IHC) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), Immunoelectron Microscopy (IEM) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1)
Conjugates Biotin (7), Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), FITC (5), PE,Cy5.5 (5), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), Gold (3), HRP (3), PE (3), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes AA 101-150 (18), pSer261,pSer264 (17), C-Term (9), pSer261 (7), N-Term (6), pSer264 (4), pSer269 (4), Phosphospecific (3), 4th Cytoplasmic Domain (1), Internal Region (1), pSer256 (1), pThr236 (1), pThr743 (1), pTyr283 (1)