ATAD5 (ATPase Family AAA) (N-Term) antibody

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Immunohistochemistry (IHC)
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ATAD5(ATPase family AAA domain-containing protein 5)
Background ATAD5(ATPase family AAA domain-containing protein 5) is involved in DNA damage response. ATAD5 is also involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. ATAD5 modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. ATAD5 interacts with RB1 predominantly in G1 phase via its LXCXE motif. ATAD5 interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents. ATAD5 is phosphorylated upon DNA damage, probably by ATM or ATR. ATR may stimulate the RAD9A dissociation. ATAD5 belongs to the AAA ATPase family.
Synonyms: C17orf41, FRAG1(Chromosome fragility-associated gene 1 protein)
Restrictions For Research Use only
Background publications Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Cantin, Yi, Lu, Park, Xu, Lee, Yates: "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." in: Journal of proteome research, Vol. 7, Issue 3, pp. 1346-51, 2008 (PubMed).

Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Ishii, Inageta, Mimori, Saito, Sasaki, Isobe, Mori, Croce, Huebner, Ozawa, Furukawa: "Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 27, pp. 9655-60, 2005 (PubMed).

Product cited in: Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Jenne, Tinschert, Reimann, Lasinger, Thiel, Hameister, Kehrer-Sawatzki: "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions." in: American journal of human genetics, Vol. 69, Issue 3, pp. 516-27, 2001 (PubMed).