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ATAD5 (ATPase Family AAA) (N-Term) antibody

Details for Product No. ABIN965604
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Antigen
Epitope
N-Term
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
Pubmed 6 references available
Quantity 0.1 mg
Options
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Availability Will be delivered in 5 to 7 Business Days
Catalog No. ABIN965604
452.38 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ATAD5(ATPase family AAA domain-containing protein 5)
Background ATAD5(ATPase family AAA domain-containing protein 5) is involved in DNA damage response. ATAD5 is also involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. ATAD5 modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. ATAD5 interacts with RB1 predominantly in G1 phase via its LXCXE motif. ATAD5 interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents. ATAD5 is phosphorylated upon DNA damage, probably by ATM or ATR. ATR may stimulate the RAD9A dissociation. ATAD5 belongs to the AAA ATPase family.
Synonyms: C17orf41, FRAG1(Chromosome fragility-associated gene 1 protein)
Restrictions For Research Use only
Product cited in: Jenne, Tinschert, Reimann et al.: "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions." in: American journal of human genetics, Vol. 69, Issue 3, pp. 516-27, 2001 (PubMed).

Ishii, Inageta, Mimori et al.: "Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 27, pp. 9655-60, 2005 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Cantin, Yi, Lu et al.: "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." in: Journal of proteome research, Vol. 7, Issue 3, pp. 1346-51, 2008 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN965604
452.38 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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