anti-Ataxin 10 antibody (ATXN10) (C-Term)

Details for Product anti-ATXN10 Antibody No. ABIN965623
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Antigen
Synonyms ATXN10, MGC97716, atxn10, Ataxin-10, si:dkeyp-15g12.2, E46L, HUMEEP, SCA10, Sca10, AI325283, C77170, E46, TEG-169, Tex169
Epitope
C-Term
(5), (4), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(35), (18), (17)
Host
Rabbit
(34), (2)
Clonality
Polyclonal
Conjugate
This Ataxin 10 antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(25), (10), (9), (8), (7), (4), (4), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATXN10(Ataxin-10)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ATXN10 (ATXN10 Antibody Abstract)
Background The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10. SCA10 is an autosomal dominant disorder and is predominantly characterized by cerebellar ataxia seizures. In addition patients often show soft pyramidal signs, ocular dyskinesia, cognitive impairment, and/or behavioral disturbances. SCA10 has been recognized only in families of Mexican origin. The molecular basis of the disease is due to an ATTCT nucleotide repeat expansion in intron 9.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Matsuura, Fang, Pearson et al.: "Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?" in: American journal of human genetics, Vol. 78, Issue 1, pp. 125-9, 2005 (PubMed).

Wiemann, Weil, Wellenreuther et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." in: Genome research, Vol. 11, Issue 3, pp. 422-35, 2001 (PubMed).

Matsuura, Yamagata, Burgess et al.: "Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10." in: Nature genetics, Vol. 26, Issue 2, pp. 191-4, 2000 (PubMed).

Validation Images
Catalog No. ABIN965623
385.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
385.00 $

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