Calpain 3 antibody (C-Term)
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- Target See all Calpain 3 (CAPN3) Antibodies
- Calpain 3 (CAPN3)
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Calpain 3 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Purification
- Purified by antigen-specific affinity chromatography.
- Immunogen
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CAPN3(Calpain-3)
- Top Product
- Discover our top product CAPN3 Primary Antibody
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- Application Notes
- ELISA, Western blotting: 1µg/ml for 2hrs.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- This antibody is stored in PBS, 50% glycerol
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- Calpain 3 (CAPN3)
- Alternative Name
- CAPN3 (CAPN3 Products)
- Background
- CAPN3(Calpain-3) is a calcium-regulated non-lysosomal thiol-protease. It has a broad endopeptidase specificity. CAPN3 is activated by micromolar concentrations of calcium and inhibited by calpastatin. It interacts with TTN/titin. Isoform I is skeletal muscle specific. Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is both autosomal dominantly and recessively transmitted. It is characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. CAPN3 belongs to the peptidase C2 family and contains 1 calpain catalytic domain and 4 EF-hand domains.
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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