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Chromodomain Helicase DNA Binding Protein 3 (CHD3) antibody

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Synonyms CG9594, CHD-3, CHD3, DmCHD3, Dmel\\CG9594, chd3, dCHD3, LOC568230, zfh, mi-2a, mi2-alpha, Mi-2a, Mi2-ALPHA, ZFH, 2600010P09Rik, AF020312, Chd7, Prp7, Prp9-1
Human, Mouse (Murine)
(59), (29), (17), (2), (1), (1)
(33), (32), (2)
Clonality (Clone)
Monoclonal ()
(3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(43), (24), (17), (17), (14), (13), (13), (11), (6), (3), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Purified recombinant fragment of human CHD3 expressed in E. Coli.
Clone 2G4
Isotype IgG1
Purification Ascitic fluid
Alternative Name CHD3 (CHD3 Antibody Abstract)
Background This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Synonyms: ZFH, Mi-2a, Mi2ALPHA, CHD3
Molecular Weight 226kDa
Gene ID 1107
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Burd, Kinyamu, Miller et al.: "UV radiation regulates Mi-2 through protein translation and stability." in: The Journal of biological chemistry, Vol. 283, Issue 50, pp. 34976-82, 2008 (PubMed).

Goehler, Lalowski, Stelzl et al.: "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. ..." in: Molecular cell, Vol. 15, Issue 6, pp. 853-65, 2004 (PubMed).

Lepesheva, Virus, Waterman: "Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function." in: Biochemistry, Vol. 42, Issue 30, pp. 9091-101, 2003 (PubMed).

Catalog No. ABIN965879
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